Internal Medicine - Atherosclerosis/Lipids News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Articles

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

181 Acute Consumption of Walnuts and Walnut Components Differentially Affect Postprandial Lipemia, Endothelial Function, Oxidative Stress, and Cholesterol Efflux in Humans with Mild Hypercholesterolemia The Journal of Nutrition, April 25, 2013 Clinical Article

182 Improved Hepatic Lipid Composition Following Short-Term Exercise in Non-Alcoholic Fatty Liver Disease Journal of Clinical Endocrinology and Metabolism, April 25, 2013 Review Article

183 Effect of insulin analog initiation therapy on LDL/HDL subfraction profile and HDL associated enzymes in type 2 diabetic patients Full Text Lipids in Health and Disease, April 25, 2013 Evidence Based Medicine

184 Fibrinolysis or Primary PCI in ST-Segment Elevation Myocardial Infarction New England Journal of Medicine, April 24, 2013 Continuing Medical Education

185 Recognition and management of masked hypertension: A review and novel approach Journal of the American Society of Hypertension, April 24, 2013 Review Article

186 Telmisartan as a metabolic sartan: The first meta-analysis of randomized controlled trials in metabolic syndrome Journal of the American Society of Hypertension, April 24, 2013 Clinical Article

187 Paroxysmal atrial fibrillation after ischemic stroke: how should we hunt for it? Expert Review of Cardiovascular Therapy , April 24, 2013 Review Article

188 Selection and timing for invasive therapy in non-ST-segment-elevation acute coronary syndrome Expert Review of Cardiovascular Therapy , April 24, 2013 Review Article

189 HIV Infection and the Risk of Acute Myocardial Infarction JAMA Internal Medicine, April 24, 2013 Clinical Article

190 Utility of established cardiovascular disease risk score models for the 10-year prediction of disease outcomes in women Expert Review of Cardiovascular Therapy , April 24, 2013 Review Article

191 Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study Kidney International, April 24, 2013 Clinical Article

192 Comparison of Therapeutic Lipid Target Achievements Among High-Risk Patients in Oman Angiology, April 24, 2013 Clinical Article

193 Symptomatic Mesenteric Atherosclerotic Disease--Lessons Learned from the Diagnostic Workup Journal of Gastrointestinal Surgery, April 24, 2013 Clinical Article

194 Lipid peroxidation affects red blood cells membrane properties in patients with systemic lupus erythematosus Clinical Hemorheology and Microcirculation, April 24, 2013 Review Article

195 Role of HDL Dysfunction in End-Stage Renal Disease: A Double-Edged Sword Journal of Renal Nutrition, April 24, 2013 Clinical Article

196 Pulmonary hypertension: diagnosis and management British Medical Journal, April 23, 2013 Continuing Medical Education Review Article

197 Cost-effectiveness of cardiovascular magnetic resonance in the diagnosis of coronary heart disease: an economic evaluation using data from the CE-MARC study Heart, April 23, 2013 Clinical Article

198 Nutrigenetics and Nutrigenomics of Atherosclerosis Current Atherosclerosis Reports, April 23, 2013 Review Article

199 Intensive treatment of persistent microalbuminuria: determinants of treatment resistance Central European Journal of Medicine, April 23, 2013 Clinical Article
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200 Association of arterial stiffness and diabetes with triglycerides-to-HDL cholesterol ratio for Japanese men: The Nagasaki Islands Study Atherosclerosis, April 23, 2013 Clinical Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2012

1 Walking Versus Running for Hypertension, Cholesterol, and Diabetes Mellitus Risk Reduction Arteriosclerosis, Thrombosis, and Vascular Biology, April 17, 2013

2 Role of exercise in the prevention of cardiovascular disease: results, mechanisms, and new perspectives European Heart Journal, April 11, 2013

3 Renin-angiotensin system inhibitors for prevention of recurrent atrial fibrillation: a meta-analysis International Journal of Clinical Practice, April 9, 2013 Evidence Based Medicine Review Article

4 L-Carnitine in the Secondary Prevention of Cardiovascular Disease: Systematic Review and Meta-analysis Mayo Clinic Proceedings, April 19, 2013 Evidence Based Medicine Review Article

5 Six-Minute Walk Test: An Effective and Necessary Tool in Modern Cardiac Rehabilitation The Hellenic Journal of Cardiology, April 16, 2013 Free full text Review Article

6 Mortality and Morbidity During and After Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial Hypertension, April 19, 2013

7 Effect of seven-day atorvastatin pretreatment on the incidence of periprocedural myocardial infarction following percutaneous coronary intervention in patients receiving long-term statin therapy. A randomized study International Journal of Cardiology, April 19, 2013

8 The Importance of 24-Hour Ambulatory Blood Pressure Monitoring in Patients at Risk of Cardiovascular Events High Blood Pressure & Cardiovascular Prevention, April 16, 2013

9 Is Overweight a Risk of Early Atherosclerosis in Childhood? Angiology, February 28, 2013

10 Cholesterol and prostate cancer Current Opinion in Pharmacology , February 4, 2013

11 Vitamin D Levels for Preventing Acute Coronary Syndrome and Mortality: Evidence of a Non-Linear Association Journal of Clinical Endocrinology and Metabolism, March 27, 2013
Exclusive Author Commentary

12 Omega-3 fatty acids: Benefits for cardio-cerebro-vascular diseases Atherosclerosis, December 5, 2012

13 Oxygen therapy in acute coronary syndrome: are the benefits worth the risk? European Heart Journal, April 8, 2013 Review Article

14 Primary Prevention of Cardiovascular Disease with a Mediterranean Diet New England Journal of Medicine, April 8, 2013 Free full text

15 Testosterone and cardiovascular risk Internal and Emergency Medicine, March 21, 2013

16 Chlorthalidone Versus Hydrochlorothiazide for the Treatment of Hypertension in Older Adults A Population-Based Cohort Study Annals of Internal Medicine, March 19, 2013

17 Cell Therapy of Peripheral Arterial Disease Circulation Research, April 29, 2013

18 Cardiovascular events after clarithromycin use in lower respiratory tract infections: analysis of two prospective cohort studies British Medical Journal, April 10, 2013 Free full text

19 The endocrinology of exercise Internal and Emergency Medicine, March 27, 2013 Review Article
Exclusive Author Commentary

20 Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial The Lancet, April 18, 2013

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Atherosclerosis/Lipids News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine