Internal Medicine - Gastroenterology News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

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1 Prevalence and risk factors of extrapancreatic malignancies in a large cohort of patients with intraductal papillary mucinous neoplasm (IPMN) of the pancreas Annals of Oncology, May 17, 2013 Clinical Article

2 C-Reactive Protein, Lipid-soluble Micronutrients, and Survival in Colorectal Cancer Patients Cancer Epidemiology, Biomarkers & Prevention, May 17, 2013 Clinical Article

3 A novel mutation within a transmembrane helix of the bile salt export pump (BSEP, ABCB11) with delayed development of liver cirrhosis Liver International, May 17, 2013 Review Article

4 Histogenesis and prognostic value of myenteric spread in colorectal cancer: a Japanese multi-institutional study Journal of Gastroenterology, May 17, 2013 Review Article

5 Mucosal healing with oral tacrolimus is associated with favorable medium- and long-term prognosis in steroid-refractory/dependent ulcerative colitis patients Journal of Crohn's and Colitis, May 17, 2013 Review Article

6 Impact of Hepatitis C Virus Infection on Bone Mineral Density in Renal Transplant Recipients PLOS ONE, May 17, 2013 Clinical Article

7 A large nationwide population-based case-control study of the association between intussusception and later celiac disease Full Text BMC Gastroenterology, May 17, 2013 Clinical Article

8 The effect of different dosing regimens of motesanib on the gallbladder: a randomized phase 1b study in patients with advanced solid tumors Full Text BMC Cancer, May 17, 2013 Clinical Article

9 Chemotherapeutic and Targeted Strategies for Locally Advanced and Metastatic Esophageal Cancer Journal of Thoracic Oncology, May 17, 2013 Review Article

10 Celiac Disease and Autoimmunity: Review and Controversies Current Allergy and Asthma Reports, May 17, 2013 Review Article

11 Cruciferous vegetables consumption and gastric cancer risk: a meta-analysis of epidemiological studies Cancer Science, May 17, 2013 Evidence Based Medicine

12 Esophageal atresia: metaplasia, Barrett Diseases of the Esophagus, May 17, 2013 Review Article

13 Refractory strictures post-esophageal atresia repair: what are the alternatives? Diseases of the Esophagus, May 17, 2013 Review Article

14 Long-term respiratory complications of congenital esophageal atresia with or without tracheoesophageal fistula: an update Diseases of the Esophagus, May 17, 2013 Review Article

15 Genetic and cellular mechanisms of the formation of esophageal atresia and tracheoesophageal fistula Diseases of the Esophagus, May 17, 2013 Review Article

16 Esophageal atresia: long-term morbidities in adolescence and adulthood Diseases of the Esophagus, May 17, 2013 Review Article

17 Long-gap esophageal atresia: traction-growth and anastomosis - before and beyond Diseases of the Esophagus, May 17, 2013 Review Article

18 Follow-up of adult patients with repaired esophageal atresia: how, when, and for how long? Diseases of the Esophagus, May 17, 2013 Review Article

19 Phenobarbital-enhanced hepatobiliary scintigraphy in the diagnosis of biliary atresia: two decades of experience at a tertiary center Pediatric Radiology, May 17, 2013 Review Article

20 A useful panel for the diagnosis of Hirschsprung disease in rectal biopsies: calretinin immunostaining and acetylcholinesterase histochesmistry Annals of Diagnostic Pathology, May 17, 2013 Review Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Internal Medicine - Gastroenterology News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine