Internal Medicine - Gastroenterology News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

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981 Disgust and behavioral avoidance in colorectal cancer screening and treatment: a systematic review and research agenda Cancer Nursing, March 28, 2013 Review Article

982 Outcomes in patients with nonerosive reflux disease treated with a proton pump inhibitor and alginic acid ± glycyrrhetinic acid and anthocyanosides Full Text Clinical and Experimental Gastroenterology, March 28, 2013 Clinical Article

983 A Genome-Wide Association Study Identifies 2 Susceptibility Loci for Crohns Disease in a Japanese Population Gastroenterology, March 28, 2013 Clinical Article

984 Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: A randomized clinical trial Clinical Nutrition, March 27, 2013 Clinical Article

985 Hepatic And Systemic Hemodynamic Derangements Predict Early Mortality and Recovery in Patients with Acute-On-Chronic Liver Failure (Aclf) Journal of Gastroenterology and Hepatology, March 27, 2013 Review Article

986 Preoperative use of anti-TNF therapy and postoperative complications in inflammatory bowel diseases: A meta-analysis Journal of Crohn's and Colitis, March 27, 2013 Clinical Article

987 A randomized phase II study of gemcitabine and S-1 combination therapy versus gemcitabine monotherapy for advanced biliary tract cancer Cancer Chemotherapy and Pharmacology, March 27, 2013 Clinical Article

988 Everolimus in colorectal cancer Expert Opinion on Pharmacotherapy, March 27, 2013 Clinical Article

989 Prognostic and diagnostic significance of annexin a2 in colorectal cancer Colorectal Disease, March 27, 2013 Clinical Article

990 A randomised clinical trial (RCT) of a symbiotic mixture in patients with irritable bowel syndrome (IBS): effects on symptoms, colonic transit and quality of life International Journal of Colorectal Disease, March 27, 2013 Clinical Article

991 Clinical characteristics, spontaneous clearance and treatment outcome of acute hepatitis C: A single tertiary center experience Full Text Saudi Journal of Gastroenterology, March 27, 2013 Clinical Article

992 Rapid Improvement of Diabetes After Gastric Bypass Surgery: Is It the Diet or Surgery? Diabetes Care, March 27, 2013 Clinical Article

993 Individualized therapy for metastatic colorectal cancer Journal of Internal Medicine, March 27, 2013 Clinical Article

994 Association of body mass index and risk of death from pancreas cancer in Asians: findings from the Asia Cohort Consortium European Journal of Cancer Prevention, March 27, 2013 Review Article Clinical Article

995 Follow-up of premalignant lesions in patients at risk for progression to gastric cancer Endoscopy, March 27, 2013 Clinical Article

996 Diagnostic and prognostic significance of CA IX and suPAR in gastric cancer Medical Oncology, March 27, 2013 Clinical Article

997 Toward a standardized system for hepatocellular carcinoma diagnosis using computed tomography and MRI Expert Review of Gastroenterology & Hepatology, March 27, 2013 Clinical Article

998 Characteristics of Patients with Ketosis-Prone Diabetes (KPD) Presenting with Acute Pancreatitis: Implications for the Natural History and Etiology of a KPD Subgroup Endocrine Practice, March 26, 2013 Clinical Article

999 Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: A randomized clinical trial Clinical Nutrition, March 26, 2013 Clinical Article

1000 Molecular markers to predict outcome to antiangiogenic therapies in colorectal cancer: Current evidence and future perspectives Cancer Treatment Reviews, March 26, 2013 Review Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2012

1 Increasing Incidence of Celiac Disease in a North American Population The American Journal of Gastroenterology, April 8, 2013

2 Increased Odds of Interval Left-Sided Colorectal Cancer After Flexible Sigmoidoscopy Compared With Colonoscopy in Older Patients in the United States: A Population-Based Analysis of the SEER-Medicare Linked Database, 2001-2005 Mayo Clinic Proceedings, April 9, 2013 Evidence Based Medicine

3 Diarrhoea is not the only symptom that needs to be treated in patients with microscopic colitis European Journal of Internal Medicine , April 9, 2013

4 Use and indications of cholestyramine and bile acid sequestrants Internal and Emergency Medicine, April 9, 2013 Review Article

5 Effect of Mosapride Combined with Esomeprazole Improves Esophageal Peristaltic Function in Patients with Gastroesophageal Reflux Disease: A Study Using High Resolution Manometry Digestive Diseases and Sciences, April 16, 2013

6 Proton Pump Inhibitor Use and the Risk of Small Intestinal Bacterial Overgrowth: A Meta-analysis Clinical Gastroenterology and Hepatology , April 23, 2013

7 Treatment of HCV Infection by Targeting MicroRNA New England Journal of Medicine, April 2, 2013

8 Proton Pump Inhibitors and Risk of 1-Year Mortality and Rehospitalization in Older Patients Discharged From Acute Care Hospitals Proton Pump Inhibitors in Older Patients JAMA Internal Medicine, April 10, 2013

9 Interpreting an isolated raised serum alkaline phosphatase level in an asymptomatic patient British Medical Journal, April 9, 2013
Exclusive Author Commentary

10 Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: A randomized clinical trial Clinical Nutrition, March 27, 2013

11 Different types of dietary advice for women with gestational diabetes mellitus Cochrane Reviews, April 1, 2013 Review Article

12 Vitamin D and the Epidemiology of Upper Gastrointestinal Cancers: A Critical Analysis of the Current Evidence Cancer Epidemiology, Biomarkers & Prevention, April 8, 2013 Evidence Based Medicine

13 Effect of GutGard in the Management of Helicobacter pylori: A Randomized Double Blind Placebo Controlled Study Evidence-based Complementary and Alternative Medicine , April 11, 2013 Free full text

14 B vitamin intakes and incidence of colorectal cancer: results from the Women's Health Initiative Observational Study cohort American Journal of Clinical Nutrition, January 4, 2013 Review Article

15 Limited role of allergy testing in patients with eosinophilic gastrointestinal disorders Journal of Gastroenterology and Hepatology, March 26, 2013 Review Article

16 Meat, fish, and esophageal cancer risk: a systematic review and dose-response meta-analysis Nutrition Reviews, April 15, 2013 Evidence Based Medicine Review Article

17 Association Between Bilirubin and Mode of Death in Severe Systolic Heart Failure The American Journal of Cardiology, April 8, 2013

18 The role of Helicobacter pylori infection in hematological disorders European Journal of Internal Medicine , March 29, 2013 Review Article

19 Vitamin B6 and colorectal cancer: Current evidence and future directions World Journal of Gastroenterology, March 5, 2013 Free full text Evidence Based Medicine Review Article

20 Bariatric surgery for type 2 diabetes The Lancet, March 20, 2013

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Gastroenterology News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine