Internal Medicine - Endocrinology News & Articles

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Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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101 The pancreatic β cell and type 1 diabetes: innocent bystander or active participant? Trends in Endocrinology and Metabolism, May 17, 2013 Review Article

102 Elevated liver enzymes in individuals with undiagnosed diabetes in the U.S. Journal of Diabetes and its Complications, May 17, 2013 Clinical Article

103 Twenty-year trend of increasing obesity in young patients with poorly controlled type 2 diabetes at first diagnosis in urban Japan Journal of Diabetes Investigation, May 17, 2013 Clinical Article

104 Health related quality of life, reoperation rate and function in patients with diabetes mellitus and hip fracture--A 2 year follow-up study Injury, May 17, 2013 Review Article

105 Albiglutide: clinical overview of a long-acting GLP-1 receptor agonist in the treatment of Type 2 diabetes Expert Review of Endocrinology & Metabolism, May 17, 2013 Review Article

106 Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial The Lancet, May 16, 2013 Clinical Article

107 Relation between Serum Free Fatty Acids and Adiposity, Insulin Resistance and Cardiovascular Risk Factors from Adolescence to Adulthood Diabetes, May 16, 2013 Clinical Article

108 Manipulation of PBF/PTTG1IP phosphorylation status; a potential new therapeutic strategy for improving radioiodine uptake in thyroid and other tumors Journal of Clinical Endocrinology and Metabolism, May 16, 2013 Review Article

109 Genetic modifiers of cystic fibrosis-related diabetes Diabetes, May 16, 2013 Review Article
Exclusive Author Commentary

110 The Influence Of Physical Activity On Vascular Complications And Mortality In Patients With Type 2 Diabetes Mellitus Diabetes, Obesity and Metabolism, May 16, 2013 Clinical Article

111 The incidence of type 2 diabetes in the United Kingdom from 1991 to 2010 Diabetes, Obesity and Metabolism, May 16, 2013 Clinical Article

112 Solvent-free enzymatic synthesis of 1, 3-Diacylglycerols by direct esterification of glycerol with saturated fatty acids Full Text Lipids in Health and Disease, May 16, 2013 Clinical Article

113 Relationship between serum levels of triglycerides and vascular inflammation, measured as COX-2, in arteries from diabetic patients: a translational study Full Text Lipids in Health and Disease, May 16, 2013 Clinical Article

114 Subcutaneous Hydrocortisone Administration for Emergency Use in Adrenal Insufficiency European Journal of Endocrinology, May 16, 2013 Review Article

115 Shortness: an unknown phenotype of multiple endocrine neoplasia type 1 European Journal of Endocrinology, May 16, 2013 Review Article

116 Towards Renewed Health Economic Simulation of Type 2 Diabetes: Risk Equations for First and Second Cardiovascular Events from Swedish Register Data PLOS ONE, May 16, 2013 Evidence Based Medicine

117 Effect of thiazolidinediones and insulin on cognitive outcomes in ACCORD-MIND Journal of Diabetes and its Complications, May 16, 2013 Clinical Article

118 Rehabilitation outcomes of stroke patients with and without diabetes Archives of Physical Medicine and Rehabilitation, May 16, 2013 Clinical Article

119 Diabetes mellitus, but not small dense low-density lipoprotein, is predictive of cardiovascular disease: A Korean community-based prospective cohort study Journal of Diabetes Investigation, May 16, 2013 Clinical Article

120 Euglycaemic ketoacidosis in patients with and without diabetes Practical Diabetes, May 16, 2013 Review Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2012

1 Walking Versus Running for Hypertension, Cholesterol, and Diabetes Mellitus Risk Reduction Arteriosclerosis, Thrombosis, and Vascular Biology, April 17, 2013

2 Canagliflozin Compared With Sitagliptin for Patients With Type 2 Diabetes Who Do Not Have Adequate Glycemic Control With Metformin Plus Sulfonylurea: A 52-week randomized trial Diabetes Care, April 9, 2013

3 Vitamin D Levels for Preventing Acute Coronary Syndrome and Mortality: Evidence of a Non-Linear Association Journal of Clinical Endocrinology and Metabolism, March 27, 2013
Exclusive Author Commentary

4 Treatment of Iron-deficiency Anemia in Patients with Subclinical Hypothyroidism American Journal of Medicine, April 18, 2013

5 Testosterone and cardiovascular risk Internal and Emergency Medicine, March 21, 2013

6 Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels -- Results from a randomized trial European Journal of Internal Medicine , April 11, 2013

7 The endocrinology of exercise Internal and Emergency Medicine, March 27, 2013 Review Article
Exclusive Author Commentary

8 The Importance of 24-Hour Ambulatory Blood Pressure Monitoring in Patients at Risk of Cardiovascular Events High Blood Pressure & Cardiovascular Prevention, April 16, 2013

9 Predictors of diabetic nephropathy Central European Journal of Medicine, April 23, 2013

10 Masked Hypertension in Diabetes Mellitus-Treatment Implications for Clinical Practice Hypertension, April 19, 2013

11 Antihypertensive therapy: nocturnal dippers and nondippers. Do we treat them differently? Vascular Health and Risk Management, March 26, 2013 Free full text

12 Detecting and controlling diabetic nephropathy: What do we know? Cleveland Clinic Journal of Medicine, April 3, 2013 Free full text

13 Bariatric surgery for type 2 diabetes The Lancet, March 20, 2013

14 Sitagliptin pretreatment in diabetes patients presenting with acute coronary syndrome: results from the Acute Coronary Syndrome Israeli Survey (ACSIS) Cardiovascular Diabetology, March 29, 2013 Free full text

15 Effect of Morbid Obesity on In-Hospital Mortality and Coronary Revascularization Outcomes After Acute Myocardial Infarction in the United States The American Journal of Cardiology, April 5, 2013

16 Teriparatide for Idiopathic Osteoporosis in Premenopausal Women: A Pilot Study Journal of Clinical Endocrinology and Metabolism, April 5, 2013

17 Comparison of Diabetic Ketoacidosis in Patients With Type-1 and Type-2 Diabetes Mellitus The American Journal of the Medical Sciences, April 1, 2013

18 The impact of coffee on health Maturitas, February 26, 2013

19 Mortality and Morbidity During and After Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial Hypertension, April 19, 2013

20 Vildagliptin in addition to metformin improves retinal blood flow and erythrocyte deformability in patients with type 2 diabetes mellitus -- results from an exploratory study Cardiovascular Diabetology, April 12, 2013 Free full text

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Endocrinology News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine