Internal Medicine - Dermatology News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

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401 Tyrosinase modulation by five Rwandese herbal medicines traditionally used for skin treatment Journal of Ethnopharmacology , April 3, 2013 Clinical Article

402 Single application of 4% dimeticone liquid gel versus two applications of 1% permethrin creme rinse for treatment of head louse infestation: a randomised controlled trial Full Text BMC Dermatology, April 3, 2013 Clinical Article
Exclusive Author Commentary

403 Anvirzel in combination with cisplatin in breast, colon, lung, prostate, melanoma and pancreatic cancer cell lines Full Text BMC Pharmacology & Toxicology, April 3, 2013 Clinical Article

404 Clinical Trial: Comparative Effectiveness of Cephalexin Plus Trimethoprim-Sulfamethoxazole Versus Cephalexin Alone for Treatment of Uncomplicated Cellulitis: A Randomized Controlled Trial Clinical Infectious Diseases, April 3, 2013 Clinical Article

405 Effect of vitamin D supplementation and ultraviolet B exposure on serum 25-hydroxyvitamin D concentrations in healthy volunteers: a randomized, crossover clinical trial British Journal of Dermatology, April 2, 2013 Clinical Article

406 Fingernail psoriasis reconsidered: A case-control study Journal of the American Academy of Dermatology, April 2, 2013 Clinical Article

407 Double dose of cetirizine hydrochloride is effective for patients with urticaria resistant: a prospective, randomized, non-blinded, comparative clinical study and assessment of quality of life Journal of Dermatological Treatment , April 2, 2013 Clinical Article

408 Streptococcus sanguinis and the sera of patients with Behçets disease stimulate membrane expression of α-enolase in human dermal microvascular endothelial cells Archives of Dermatological Research, April 2, 2013 Clinical Article

409 Insulin-like growth factor-binding protein-7 (IGFBP7) transcript: A-to-I editing events in normal and cancerous human keratinocytes Archives of Dermatological Research, April 2, 2013 Clinical Article

410 Streptococcal infections of skin and PANDAS Dermatologic Therapy, April 2, 2013 Clinical Article

411 Randomized controlled trial comparing photodynamic therapy based on methylene blue dye and fluconazole for toenail onychomycosis Dermatologic Therapy, April 2, 2013 Clinical Article

412 Levamisole-induced myopathy and leukocytoclastic vasculitis: a case report and literature review Dermatologic Therapy, April 2, 2013 Review Article

413 Congenital Myxoid and Pigmented Dermatofibrosarcoma Protuberans: A Case Report Pediatric Dermatology, April 2, 2013

414 The role of radiotherapy for large and locally advanced non-melanoma skin carcinoma Journal of Radiotherapy in Practice, April 2, 2013 Review Article

415 Survival of an elderly patient with limited cutaneous systemic sclerosis, pretamponade and pulmonary hypertension International Journal of Clinical Rheumatology, April 2, 2013

416 Predicting treatment response in psoriasis using serum levels of adalimumab and etanercept: a single centre, cohort study British Journal of Dermatology, April 1, 2013 Clinical Article

417 Extracorporeal photopheresis: a useful therapy for patients with steroids refractory acute graft versus host disease but not for the prevention of the chronic form British Journal of Dermatology, April 1, 2013 Clinical Article

418 Diagnostic Criteria for Erosive Lichen Planus Affecting the Vulva: An international electronic-Delphi Consensus Exercise British Journal of Dermatology, April 1, 2013 Review Article Clinical Article

419 Association of discoid lupus erythematosus with other clinical manifestations among patients with systemic lupus erythematosus Journal of the American Academy of Dermatology, April 1, 2013 Clinical Article

420 Age-related changes in the composition of the cornified envelope in human skin Experimental Dermatology, April 1, 2013 Clinical Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2012

1 Effect of vitamin D supplementation and ultraviolet B exposure on serum 25-hydroxyvitamin D concentrations in healthy volunteers: a randomized, crossover clinical trial British Journal of Dermatology, April 2, 2013

2 Outpatient parenteral antimicrobial therapy British Medical Journal, April 12, 2013

3 A clinical study of melasma and a comparison of the therapeutic effect of certain currently available topical modalities for its treatment Indian Journal of Dermatology, April 22, 2013 Free full text

4 Focusing and depth of field in photography: application in dermatology practice Skin Research and Technology, April 3, 2013 Review Article

5 Prevention of nonsteroidal inflammatory drug-induced urticaria and/or angioedema Annals of Allergy, Asthma, and Immunology, March 28, 2013

6 Surgeon error and slide quality during Mohs micrographic surgery: Is there a relationship with tumor recurrence Journal of the American Academy of Dermatology, April 16, 2013
Exclusive Author Commentary

7 Skin Conditions of Baseball, Cricket, and Softball Players Sports Medicine, April 5, 2013 Review Article

8 Practical guidelines for the use of steroid-sparing agents in the treatment of chronic pruritus Dermatologic Therapy, April 10, 2013

9 Diet and nutrition in psoriasis: analysis of the National Health and Nutrition Examination Survey (NHANES) in the United States Journal of the European Academy of Dermatology and Venereology, March 5, 2013 Review Article

10 The comparative effectiveness of suction-curettage and onabotulinumtoxin-A injections for the treatment of primary focal axillary hyperhidrosis: A randomized control trial Journal of the American Academy of Dermatology, April 16, 2013

11 The use of green tea extract in cosmetic formulations: not only an antioxidant active ingredient Dermatologic Therapy, March 14, 2013

12 Serum Ferritin and Vitamin D in Female Hair Loss: Do They Play a Role Skin Pharmacology and Physiology, February 20, 2013

13 Phase I/II and Pharmacodynamic Study of Dovitinib (TKI258)-an Inhibitor of Fibroblast Growth Factor Receptors and VEGF Receptors-in Patients with Advanced Melanoma Clinical Cancer Research, October 7, 2011 Free full text

14 New era of biologic therapeutics in atopic dermatitis Expert Opinion on Biological Therapy, March 21, 2013

15 A Systematic Review of SAPHO Syndrome and Inflammatory Bowel Disease Association Digestive Diseases and Sciences, April 16, 2013

16 Common Misconceptions About Lyme Disease American Journal of Medicine, March 7, 2013 Review Article

17 Psoriasis Is Not Associated with Atherosclerosis and Incident Cardiovascular Events: The Rotterdam Study Journal of Investigative Dermatology, April 15, 2013

18 Clinical activity and safety of combination therapy with temsirolimus and bevacizumab for advanced melanoma: A Phase II trial (CTEP 7190/ Mel47) Clinical Cancer Research, April 26, 2013

19 Chloroquine Promotes Apoptosis in Melanoma Cells by Inhibiting BH3 Domain–Mediated PUMA Degradation Journal of Investigative Dermatology, March 27, 2013

20 The relationship between severity of the disease and circulating nucleosomes in psoriasis patients Archives of Dermatological Research, April 16, 2013

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Dermatology News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine