Internal Medicine - Clinical Pharmacology News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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1 Targeted use of heparin, heparinoids, or low-molecular-weight heparin to improve outcome after acute ischaemic stroke: an individual patient data meta-analysis of randomised controlled trials The Lancet Neurology, May 17, 2013 Evidence Based Medicine Review Article Clinical Article

2 Cost-Effectiveness of Duloxetine in Chronic Low Back Pain: A Quebec Societal Perspective Spine, May 17, 2013 Evidence Based Medicine Clinical Article

3 Impact of Adding Ezetimibe to Statin to Achieve Low-Density Lipoprotein Cholesterol Goal (from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation [COURAGE] Trial) The American Journal of Cardiology, May 17, 2013 Clinical Article

4 Prescription Opioids for Back Pain and Use of Medications for Erectile Dysfunction Spine, May 17, 2013 Evidence Based Medicine Clinical Article

5 Spinal Injection Therapy for Low Back Pain JAMA, May 17, 2013 Clinical Article

6 Adulterated Sexual Enhancement Supplements: More Than Mojo JAMA Internal Medicine, May 17, 2013 Review Article Clinical Article

7 A dose-ranging study of cabozantinib in men with castration-resistant prostate cancer and bone metastases Clinical Cancer Research, May 17, 2013 Clinical Article

8 Anti tumor Necrosis Factor - Alpha Adalimumab for Complex Regional Pain Syndrome Type 1 (CRPS-I): A Case Series Pain Practice, May 17, 2013 Clinical Article

9 Triple therapy with deferiprone, idebenone and riboflavin in Friedreich's ataxia – open-label trial Acta Neurologica Scandinavica, May 17, 2013 Clinical Article

10 Phenothiazines Inhibit Hepatitis C Virus Entry, Likely by Increasing the Fluidity of Cholesterol-Rich Membranes Antimicrobial Agents and Chemotherapy, May 17, 2013 Review Article

11 Influence of compliance on bone mineral density changes in postmenopausal women with early breast cancer on Anastrozole Journal of Cancer Research & Clinical Oncology, May 17, 2013 Clinical Article

12 Cost analysis of glatiramer acetate vs. fingolimod for the treatment of patients with relapsing-remitting multiple sclerosis in Spain Full Text Health Economics Review, May 17, 2013 Clinical Article

Prior Articles

13 Ibuprofen with or without an antiemetic for acute migraine headaches in adults Cochrane Reviews, May 16, 2013 Evidence Based Medicine Clinical Article

14 Differential Effects of Nebivolol Versus Metoprolol on Functional Sympatholysis in Hypertensive Humans Hypertension, May 16, 2013 Clinical Article

15 Interventions to improve antibiotic prescribing practices for hospital inpatients Cochrane Reviews, May 16, 2013 Evidence Based Medicine

16 Galantamine for vascular cognitive impairment Cochrane Reviews, May 16, 2013 Evidence Based Medicine Clinical Article

17 Pharmacokinetic Considerations for the Use of Levodopa in the Treatment of Parkinson Disease: Focus on Levodopa/Carbidopa/Entacapone for Treatment of Levodopa-Associated Motor Complications Clinical Neuropharmacology, May 16, 2013 Clinical Article

18 Differential Effects of the (beta)-Adrenoceptor Blockers Carvedilol and Metoprolol on SQT1- and SQT2-Mutant Channels Journal of Cardiovascular Electrophysiology, May 16, 2013 Clinical Article

19 Tardive Dyskinesia Caused by Tetrabenazine Clinical Neuropharmacology, May 16, 2013 Clinical Article

20 Relationship between aspirin/clopidogrel resistance and intra-stent thrombi assessed by follow-up optical coherence tomography after drug-eluting stent implantation European Heart Journal – Cardiovascular Imaging, May 16, 2013 Clinical Article

50 available pages FirstPrevious 1 2 3 4 5 6 7 8 9 10 Next Last

Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Internal Medicine - Clinical Pharmacology News & Articles

Articles

Prior Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine