Internal Medicine - Neurology News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Articles

Latest (43) Full Text Articles (1074) Focus on Substance Abuse

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

81 Rapid cell death is preceded by amyloid plaque-mediated oxidative stress Proceedings of the National Academy of Sciences of the United States of America, May 15, 2013 Review Article

82 Callosal degeneration topographically correlated with cognitive function in amnestic mild cognitive impairment and alzheimers disease dementia Human Brain Mapping, May 15, 2013 Clinical Article

83 Common and unique gray matter correlates of episodic memory dysfunction in frontotemporal dementia and alzheimers disease Human Brain Mapping, May 15, 2013 Clinical Article

84 Acute and subacute IL-1beta administrations differentially modulate neuroimmune and neurotrophic systems: possible implications for neuroprotection and neurodegeneration Full Text Journal of Neuroinflammation, May 15, 2013 Clinical Article
Exclusive Author Commentary

85 Current prospects and challenges for epilepsy gene therapy Experimental Neurology, May 15, 2013 Review Article

86 Cortical and Subcortical Cerebrovascular Resistance Index in Mild Cognitive Impairment and Alzheimers Disease Journal of Alzheimer’s Disease, May 15, 2013 Clinical Article

87 Effectiveness and Safety of Memantine Treatment for Alzheimers Disease Journal of Alzheimer’s Disease, May 15, 2013 Clinical Article

88 Safe Treatment of Seizures in the Setting of HIV/AIDS Current Treatment Options in Neurology, May 15, 2013 Clinical Article

89 In-hospital case management to increase anticoagulation therapy for stroke patients with atrial fibrillation: A hospital-based registry Journal of the Formosan Medical Association, May 15, 2013 Clinical Article

90 Passive anti-amyloid immunotherapy in Alzheimers disease: What are the most promising targets? Full Text Immunity & Ageing, May 15, 2013 Clinical Article

91 Rehabilitation Interventions for Unilateral Neglect after Stroke: A Systematic Review from 1997 through 2012 Frontiers in Neurology, May 15, 2013 Evidence Based Medicine Review Article

92 Factors predictive of the development of levodopa-induced dyskinesia and wearing-off in Parkinsons disease Movement Disorders, May 15, 2013 Clinical Article

93 SNCA: Major genetic modifier of age at onset of Parkinsons disease Movement Disorders, May 15, 2013 Clinical Article

94 Mutations in Extracellular Matrix Genes NID1 and LAMC1 Cause Autosomal Dominant Dandy–Walker Malformation and Occipital Cephaloceles Human Mutation, May 15, 2013 Review Article

95 Nicotine from edible Solanaceae and risk of Parkinson disease Annals of Neurology , May 15, 2013 Review Article

96 Could Sensory Mechanisms Be a Core Factor That Underlies Freezing of Gait in Parkinson's Disease? PLOS ONE, May 15, 2013 Review Article
Exclusive Author Commentary

97 Impact of Scotland’s Comprehensive, Smoke-Free Legislation on Stroke PLOS ONE, May 15, 2013 Review Article

98 Aspirin nonresponders in patients with ischaemic stroke Blood Coagulation & Fibrinolysis, May 14, 2013 Clinical Article

99 Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults Cochrane Reviews, May 14, 2013 Evidence Based Medicine Clinical Article

100 Posttraumatic stress disorder and cardiovascular disease Progress in Cardiovascular Diseases , May 14, 2013 Review Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2012

1 Duration of Migraine Is Associated with Cardiac Diastolic Dysfunction Pain Medicine, April 19, 2013

2 Combination Antifungal Therapy for Cryptococcal Meningitis New England Journal of Medicine, April 8, 2013

3 The effect of black tea and caffeine on regional cerebral blood flow measured with arterial spin labeling Journal of Cerebral Blood Flow & Metabolism, April 2, 2013

4 Effects of the Finnish Alzheimer Disease Exercise Trial (FINALEX) A Randomized Controlled Trial Effects of FINALEX JAMA Internal Medicine, April 16, 2013

5 Calcium antagonists as an add-on therapy for drug-resistant epilepsy Cochrane Reviews, April 2, 2013 Review Article

6 Prevalence of Migraine and Raynaud Phenomenon in Women With Apical Ballooning Syndrome (Takotsubo or Stress Cardiomyopathy) The American Journal of Cardiology, April 26, 2013

7 Advances in Stroke Prevention in Atrial Fibrillation: Enhanced Risk Stratification Combined With the Newer Oral Anticoagulants Clinical Cardiology, April 11, 2013 Free full text Review Article

8 Diagnosing tuberculous meningitis ? have we made any progress? Tropical Medicine & International Health, March 27, 2013 Review Article

9 Dental Prophylaxis and Periodontal Treatment Are Protective Factors to Ischemic Stroke Stroke, April 10, 2013

10 Incidence of atrial fibrillation detected by implantable loop recorders in unexplained stroke Neurology, April 18, 2013

11 Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study The Lancet Neurology, April 23, 2013

12 Corticosteroids for preventing postherpetic neuralgia Cochrane Reviews, April 3, 2013 Evidence Based Medicine

13 Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study British Medical Journal, April 23, 2013 Free full text

14 Herpes Zoster Vaccine Effectiveness against Incident Herpes Zoster and Post-herpetic Neuralgia in an Older US Population: A Cohort Study PLoS Medicine, April 12, 2013 Free full text

15 Methylation of the hTERT Promoter: A Novel Cancer Biomarker for Leptomeningeal Metastasis Detection in Cerebrospinal Fluids Clinical Cancer Research, April 18, 2013 Review Article

16 Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic Stroke New England Journal of Medicine, March 25, 2013

17 Quetiapine for the treatment of delirium Journal of Hospital Medicine, March 21, 2013

18 Management of Painful Peripheral Diabetic Neuropathy British Journal of Medical Practitioners, April 2, 2013 Free full text

19 Update: Idiopathic Adult Growth Hormone Deficiency Journal of Clinical Endocrinology and Metabolism, April 5, 2013

20 Migraine, headache, and the risk of depression: Prospective cohort study Cephalalgia, April 16, 2013

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Neurology News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine