Internal Medicine - Basic Science/Genetics News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Articles

Latest (22) Full Text Articles (1124) Focus on Heart Failure

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

141 Intravascular ultrasound comparison of the self-expanding sideguard stent in the side branch versus a balloon-expandable stent in the main vessel to assess mechanisms of acute Lumen Gain in Bifurcation Lesions Catheterization and Cardiovascular Interventions, May 1, 2013 Clinical Article

142 Impact of polyvascular disease on clinical outcomes in patients undergoing coronary revascularization: An observation from the CREDO-Kyoto Registry Cohort-2 Atherosclerosis, May 1, 2013 Clinical Article

143 Platelet Inhibitory Effect of Clopidogrel in Patients Treated With Omeprazole, Pantoprazole, and Famotidine: A Prospective, Randomized, Crossover Study Full Text Clinical Cardiology, May 1, 2013 Clinical Article

144 Mechanisms and novel therapeutic approaches of wasting in chronic disease Maturitas, May 1, 2013 Clinical Article

145 Carotid artery stenting: Patient, lesion, and procedural characteristics that increase procedural complications Catheterization and Cardiovascular Interventions, May 1, 2013 Clinical Article

146 Heart Transplantation and Left Ventricular Assist Device Therapy: Two Comparable Options in End-Stage Heart Failure? Full Text Clinical Cardiology, May 1, 2013 Clinical Article

147 Pregnancy Loss and Later Risk of Atherosclerotic Disease Circulation, May 1, 2013 Clinical Article
Exclusive Author Commentary

148 Mid-term prognostic value of coronary artery disease in patients undergoing transcatheter aortic valve implantation: A meta-analysis of adjusted observational results International Journal of Cardiology, May 1, 2013 Evidence Based Medicine Clinical Article

149 New perspectives on evolutionary medicine: the relevance of microevolution for human health and disease Full Text BMC Medicine, May 1, 2013

150 Dominant effects of the Huntington's disease HTT CAG repeat length are captured in gene-expression data sets by a continuous analysis mathematical modeling strategy Human Molecular Genetics, May 1, 2013 Review Article

151 The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation Human Molecular Genetics, May 1, 2013 Review Article

152 Cis-silencing of PIP5K1B evidenced in Friedreich's ataxia patient cells results in cytoskeleton anomalies Human Molecular Genetics, May 1, 2013 Review Article

153 Mutations in GFPT1 that underlie limb-girdle congenital myasthenic syndrome result in reduced cell-surface expression of muscle AChR Human Molecular Genetics, May 1, 2013 Review Article

154 Recurrent Pericarditis in Myhre Syndrome American Journal of Medical Genetics Part A, May 1, 2013 Review Article

155 Clinical Comparison of Overlapping Deletions of 19p13.3 American Journal of Medical Genetics Part A, May 1, 2013 Review Article

156 What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn Full Text Molecular Psychiatry, May 1, 2013 Review Article

157 Effects of insulin and IGF-I on growth hormone- induced STAT5 activation in 3T3-F442A adipocytes Full Text Lipids in Health and Disease, May 1, 2013

158 Randomized trial comparing the efficacy between different types of paclitaxel-eluting stents: The comparison of Efficacy between COroflex PLEASe ANd Taxus stent (ECO-PLEASANT) randomized controlled trial American Heart Journal, April 30, 2013 Clinical Article

159 Contrast-induced acute kidney injury and clinical outcomes after intra-arterial and intravenous contrast administration: Risk comparison adjusted for patient characteristics by design American Heart Journal, April 30, 2013 Clinical Article

160 Rationale and design of the LEADERS FREE trial: A randomized double-blind comparison of the BioFreedom drug-coated stent vs the Gazelle bare metal stent in patients at high bleeding risk using a short (1 month) course of dual antiplatelet therapy American Heart Journal, April 30, 2013 Clinical Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2012

1 Walking Versus Running for Hypertension, Cholesterol, and Diabetes Mellitus Risk Reduction Arteriosclerosis, Thrombosis, and Vascular Biology, April 17, 2013

2 Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial The Lancet, April 18, 2013

3 Vitamin D Levels for Preventing Acute Coronary Syndrome and Mortality: Evidence of a Non-Linear Association Journal of Clinical Endocrinology and Metabolism, March 27, 2013
Exclusive Author Commentary

4 Primary Prevention of Cardiovascular Disease with a Mediterranean Diet New England Journal of Medicine, April 8, 2013 Free full text

5 Effect of ivabradine in patients with left-ventricular systolic dysfunction: a pooled analysis of individual patient data from the BEAUTIFUL and SHIFT trials European Heart Journal, March 29, 2013

6 Renin-angiotensin system inhibitors for prevention of recurrent atrial fibrillation: a meta-analysis International Journal of Clinical Practice, April 9, 2013 Evidence Based Medicine Review Article

7 Leukaemia update. Part 1: diagnosis and management British Medical Journal, April 9, 2013 Review Article

8 Vitamin D and Calcium Supplementation to Prevent Fractures in Adults: U.S. Preventive Services Task Force Recommendation Statement Annals of Internal Medicine, February 26, 2013 Clinical Guideline

9 Single dose oral ibuprofen plus codeine for acute postoperative pain in adults Cochrane Reviews, April 1, 2013 Review Article

10 Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations The Lancet, March 26, 2013

11 Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels -- Results from a randomized trial European Journal of Internal Medicine , April 11, 2013

12 Physical Activity and Cardiovascular Disease in African Americans in ARIC Medicine and Science in Sports and Exercise, March 14, 2013

13 Biolimus-eluting biodegradable polymer-coated stent versus durable polymer-coated sirolimus-eluting stent in unselected patients receiving percutaneous coronary intervention (SORT OUT V): a randomised non-inferiority trial The Lancet, March 26, 2013

14 Iron deficiency in chronic heart failure: An international pooled analysis American Heart Journal, April 1, 2013

15 Anaphylaxis: the acute episode and beyond British Medical Journal, March 1, 2013

16 Red flags to screen for malignancy in patients with low-back pain Cochrane Reviews, March 8, 2013

17 The endocrinology of exercise Internal and Emergency Medicine, March 27, 2013 Review Article
Exclusive Author Commentary

18 Role of Fructose-Containing Sugars in the Epidemics of Obesity and Metabolic Syndrome Annual Review of Medicine, January 17, 2013 Review Article

19 Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels Journal of Internal Medicine, March 1, 2013

20 Trajectories of cardiometabolic risk factors before diagnosis of three subtypes of type 2 diabetes: a post-hoc analysis of the longitudinal Whitehall II cohort study The Lancet, March 20, 2013

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Basic Science/Genetics News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine