Internal Medicine - Basic Science/Genetics News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Articles

Latest (5) Full Text Articles (1124) Focus on Diabetes Mellitus

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

921 Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood American Journal of Clinical Nutrition, March 5, 2013 Clinical Article

922 Evaluation of the Hepatitis C Virus-Infected Patient: The Initial Encounter Clinical Infectious Diseases, March 5, 2013 Clinical Article

923 Diabetic Ketoacidosis: Evaluation and Treatment American Family Physician, March 5, 2013 Clinical Article

924 Septic shock: The initial moments and beyond Full Text Cleveland Clinic Journal of Medicine, March 5, 2013 Review Article

925 Adverse Drug Events in Older Adults American Family Physician, March 5, 2013 Clinical Article

926 The search for an HIV cure: tackling latent infection The Lancet Infectious Diseases, March 5, 2013 Clinical Article

927 Strategies for early detection of chronic Q-fever: a systematic review European Journal of Clinical Investigation, March 5, 2013 Review Article

928 Prognostic Value of Cardiac Troponin I Measured With a Highly Sensitive Assay in Patients With Stable Coronary Artery Disease Full Text JACC - Journal of the American College of Cardiology, March 5, 2013 Clinical Article

929 Transforming growth factor-beta1 deteriorates microrheological characteristics and motility of mature dendritic cells in concentration-dependent fashion Clinical Hemorheology and Microcirculation, March 5, 2013 Review Article

930 Communicating cancer risk within an African context: Experiences, disclosure patterns and uptake rates following genetic testing for Lynch syndrome Patient Education and Counselling, March 5, 2013 Clinical Article

931 Cancer-Produced Metabolites of 5-Lipoxygenase Induce Tumor-Evoked Regulatory B Cells via Peroxisome Proliferator-Activated Receptor {alpha} The Journal of Immunology, March 5, 2013 Review Article

932 Primary Prevention of Cardiovascular Disease with a Mediterranean Diet New England Journal of Medicine, March 4, 2013 Clinical Article

933 Sudden cardiac arrest associated with use of a non-cardiac drug that reduces cardiac excitability: evidence from bench, bedside, and community European Heart Journal, March 4, 2013 Clinical Article

934 The pathophysiology of elevated vitamin B12 in clinical practice QJM: An International Journal of Medicine, March 4, 2013 Review Article

935 Nocturnal Glucose Control with an Artificial Pancreas at a Diabetes Camp New England Journal of Medicine, March 4, 2013 Clinical Article

936 Nonpeptic Ulcer, Nonvariceal Gastrointestinal Bleeding in Hemodialysis Patients American Journal of Medicine, March 4, 2013 Clinical Article

937 Prostate cancer screening and the management of clinically localized disease Full Text BMC Medicine, March 4, 2013 Continuing Medical Education Review Article

938 Magnesium sulphate for women at term for neuroprotection of the fetus Cochrane Reviews, March 4, 2013 Review Article

939 HPS2-THRIVE randomized placebo-controlled trial in 25673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment European Heart Journal, March 4, 2013 Clinical Article

940 Proinsulin/Insulin Autoantibodies Measured With Electrochemiluminescent Assay Are the Earliest Indicator of Prediabetic Islet Autoimmunity Diabetes Care, March 4, 2013 Clinical Article

50 available pages First Previous 41 42 43 44 45 46 47 48 49 50 Next Last

Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

Read the article summary

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

Read the article summary

CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Med Articles

Last month's top read Top Articles of 2012

1 Anger and the Heart: Perspectives on Cardiac Risk, Mechanisms and Interventions Progress in Cardiovascular Diseases , May 1, 2013

2 Adiponectin Gene Variant Interacts with Fish Oil Supplementation to Influence Serum Adiponectin in Older Individuals The Journal of Nutrition, May 10, 2013

3 Models for estimating the biological age of five organs using clinical biomarkers that are commonly measured in clinical practice settings Maturitas, May 1, 2013
Exclusive Author Commentary

4 Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy Human Molecular Genetics, May 8, 2013 Review Article

5 Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials British Medical Journal, April 25, 2013 Evidence Based Medicine Review Article

6 A systematic scoping review of adherence to reporting guidelines in health care literature Journal of Multidisciplinary Healthcare, May 8, 2013 Evidence Based Medicine Review Article

7 Oxidized eicosapentaenoic acids more potently reduce LXRalpha-induced cellular triacylglycerol via suppression of SREBP-1c, PGC-1beta and GPA than its intact form Lipids in Health and Disease, May 21, 2013 Free full text

8 ACTA2 Mutation With Childhood Cardiovascular, Autonomic and Brain Anomalies and Severe Outcome American Journal of Medical Genetics Part A, May 8, 2013 Review Article

9 Development of the Human Aortic Arch System Captured in an Interactive Three-Dimensional Reference Model American Journal of Medical Genetics Part A, May 7, 2013 Review Article

10 Impact of age on male fertility Current Opinion in Obstetrics and Gynecology, May 14, 2013 Review Article

11 Robust evidence for five new Grave's disease risk loci from a staged genome-wide association analysis Human Molecular Genetics, May 8, 2013 Review Article

12 An Anxious Heart: Anxiety and the Onset of Cardiovascular Diseases Progress in Cardiovascular Diseases , May 1, 2013

13 Thirty years beyond discovery--Clinical trials in succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism Journal of Inherited Metabolic Disease, May 28, 2013 Review Article

14 Pulmonary hypertension: diagnosis and management British Medical Journal, April 23, 2013 Review Article

15 Outpatient parenteral antibiotic therapy: Principles and practice European Journal of Internal Medicine , April 25, 2013

16 A Novel RASA1 Mutation Causing Capillary Malformation-Arteriovenous Malformation (CM-AVM) Presenting During Pregnancy American Journal of Medical Genetics Part A, May 22, 2013 Review Article

17 Hedging, knowledge and interaction: Doctors and clients talk about medical information and client experiences in genetic counseling Patient Education and Counselling, May 20, 2013 Review Article

18 The endocrinology of exercise Internal and Emergency Medicine, March 27, 2013 Review Article
Exclusive Author Commentary

19 Walking Versus Running for Hypertension, Cholesterol, and Diabetes Mellitus Risk Reduction Arteriosclerosis, Thrombosis, and Vascular Biology, April 17, 2013

20 Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors BMC Medicine, April 25, 2013 Free full text

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Basic Science/Genetics News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Med Articles

Other Topics in Internal Medicine