Internal Medicine - Basic Science/Genetics News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Articles

Latest (13) Full Text Articles (1124) Focus on Thyroid Disease

Ranked, sorted, and summarized by MDLinx editors from the latest literature

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881 Current controversies in the use of haemoglobin A1c Journal of Internal Medicine, February 27, 2013 Review Article

882 Unravelling modifiers of breast and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: update on genetic modifiers Journal of Internal Medicine, February 27, 2013 Review Article

883 High levels of cystatin C predict the metabolic syndrome: the prospective Malmö Diet and Cancer Study Journal of Internal Medicine, February 27, 2013 Clinical Article

884 The niche under siege: novel targets for metastasis therapy Journal of Internal Medicine, February 27, 2013 Review Article

885 Metric properties and normative data for brief noise and electromagnetic field sensitivity scales Scandinavian Journal of Public Health, February 27, 2013 Review Article

886 Impact of a stepwise introduction of smoke-free legislation on the rate of preterm births: analysis of routinely collected birth data Full Text British Medical Journal, February 26, 2013 Clinical Article

887 Multiple daily injections of insulin versus continuous subcutaneous insulin infusion for pregnant women with type 1 diabetes Australian and New Zealand Journal of Obstetrics and Gynaecology, February 26, 2013 Clinical Article

888 A Systematic Review of Telestroke Postgraduate Medicine, February 26, 2013 Review Article

889 New Horizons: Current and Potential Future Self-Treatments for Acute Upper Respiratory Tract Conditions Postgraduate Medicine, February 26, 2013 Review Article

890 Saxagliptin vs. glipizide as add-on therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: long-term (52-week) extension of a 52-week randomised controlled trial International Journal of Clinical Practice, February 25, 2013 Clinical Article

891 Silodosin in the management of lower urinary tract symptoms as a result of benign prostatic hyperplasia: who are the best candidates International Journal of Clinical Practice, February 25, 2013 Review Article

892 Association of Glucocorticoid Receptor Gene NR3C1 Genetic Variants with Angiographically Documented Coronary Artery Disease and Its Risk Factors Archives of Medical Research, February 25, 2013 Evidence Based Medicine

893 Non-cardiac chest pain: time to extend the rapid access chest pain clinic? International Journal of Clinical Practice, February 25, 2013 Clinical Article

894 Does childhood nutrition influence adult cardiovascular disease risk?-Insights from the Young Finns Study Annals of Medicine, February 25, 2013 Review Article

895 Sleep Apnea and Risk of Peptic Ulcer Bleeding: A Nationwide Population-based Study American Journal of Medicine, February 25, 2013 Clinical Article

896 Phosphodiesterase Type 5 Inhibitors Improve Endothelial Function and May Benefit Cardiovascular Conditions American Journal of Medicine, February 25, 2013 Clinical Article

897 Markers of biological fitness as predictors of all-cause mortality Annals of Medicine, February 25, 2013 Review Article

898 Nordic walking decreased circulating chemerin and leptin concentrations in middle-aged men with impaired glucose regulation Annals of Medicine, February 25, 2013 Clinical Article

899 WHO recommendations for misoprostol use for obstetric and gynecologic indications International Journal of Gynecology & Obstetrics, February 25, 2013 Clinical Guideline

900 The individual and combined influence of ACE and ACTN3 genotypes on muscle phenotypes before and after strength training Scandinavian Journal of Medicine & Science in Sports, February 25, 2013 Review Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Internal Medicine - Basic Science/Genetics News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine