Internal Medicine - Basic Science/Genetics News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Articles

Latest (2) Full Text Articles (1124) Focus on HIV

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

861 The need for better insulin therapy Diabetes, Obesity and Metabolism, March 12, 2013 Review Article

862 Lack of Evidence on Tai Chi-Related Effects in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis Experimental and Clinical Endocrinology & Diabetes, March 12, 2013 Evidence Based Medicine

863 Leptins Role in Lipodystrophic and Nonlipodystrophic Insulin-Resistant and Diabetic Individuals Endocrine Reviews, March 12, 2013 Review Article

864 Interactions of the IGF System with Diabetes and its Vascular Complications Experimental and Clinical Endocrinology & Diabetes, March 12, 2013 Review Article

865 CNS relapses in patients with HER2-positive early breast cancer who have and have not received adjuvant trastuzumab: a retrospective substudy of the HERA trial (BIG 1-01) The Lancet Oncology, March 12, 2013 Clinical Article

866 Verification of correct central venous catheter placement in the emergency department: comparison between ultrasonography and chest radiography Internal and Emergency Medicine, March 12, 2013 Clinical Article

867 Interstitial lung disease European Respiratory Review, March 12, 2013 Review Article

868 C-reactive protein, bone strength, and 9-year fracture risk: Data from the study of womens health across the nation (SWAN) Journal of Bone and Mineral Research, March 12, 2013 Clinical Article

869 A threefold increase in gestational diabetes over two years: Review of screening practices and pregnancy outcomes in Indigenous women of Cape York, Australia Australian and New Zealand Journal of Obstetrics and Gynaecology, March 12, 2013 Clinical Article

870 Effect of CYP2D6*10 and APOE Polymorphisms on the Efficacy of Donepezil in Patients With Alzheimer's Disease The American Journal of the Medical Sciences, March 12, 2013 Evidence Based Medicine

871 The Role of TNF-alpha 308G>A Polymorphism in the Risk for Ischemic Stroke The American Journal of the Medical Sciences, March 12, 2013 Clinical Article

872 Orofacial Manifestations in Patients With Sickle Cell Disease The American Journal of the Medical Sciences, March 12, 2013 Clinical Article

873 Chromosome 9p21 genetic variation explains 13% of cardiovascular disease incidence but does not improve risk prediction Journal of Internal Medicine, March 12, 2013 Evidence Based Medicine

874 Trajectories of cardiometabolic risk factors before diagnosis of three subtypes of type 2 diabetes: a post-hoc analysis of the longitudinal Whitehall II cohort study The Lancet, March 11, 2013 Clinical Article

875 Low-molecular-weight lipoprotein (a) and low relative lymphocyte concentration are significant and independent risk factors for coronary heart disease in patients with type 2 diabetes mellitus: Lp(a) phenotype, lymphocyte, and coronary heart disease Full Text Lipids in Health and Disease, March 11, 2013 Clinical Article

876 Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial The Lancet, March 11, 2013 Clinical Article

877 Out-of-hospital cardiac arrest: 10 years of progress in research and treatment Journal of Internal Medicine, March 11, 2013 Clinical Article

878 Embedding non-communicable diseases in the post-2015 development agenda The Lancet, March 11, 2013 Clinical Article

879 Mutation in PHC1 Implicates Chromatin Remodeling in Primary Microcephaly Pathogenesis Human Molecular Genetics, March 11, 2013 Review Article

880 Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression Human Molecular Genetics, March 11, 2013 Review Article

50 available pages First Previous 41 42 43 44 45 46 47 48 49 50 Next Last

Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

Read the article summary

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

Read the article summary

CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

Read the article summary

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Most Popular Internal Med Articles

Last month's top read Top Articles of 2012

1 Anger and the Heart: Perspectives on Cardiac Risk, Mechanisms and Interventions Progress in Cardiovascular Diseases , May 1, 2013

2 Adiponectin Gene Variant Interacts with Fish Oil Supplementation to Influence Serum Adiponectin in Older Individuals The Journal of Nutrition, May 10, 2013

3 Models for estimating the biological age of five organs using clinical biomarkers that are commonly measured in clinical practice settings Maturitas, May 1, 2013
Exclusive Author Commentary

4 Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy Human Molecular Genetics, May 8, 2013 Review Article

5 Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials British Medical Journal, April 25, 2013 Evidence Based Medicine Review Article

6 A systematic scoping review of adherence to reporting guidelines in health care literature Journal of Multidisciplinary Healthcare, May 8, 2013 Evidence Based Medicine Review Article

7 Oxidized eicosapentaenoic acids more potently reduce LXRalpha-induced cellular triacylglycerol via suppression of SREBP-1c, PGC-1beta and GPA than its intact form Lipids in Health and Disease, May 21, 2013 Free full text

8 ACTA2 Mutation With Childhood Cardiovascular, Autonomic and Brain Anomalies and Severe Outcome American Journal of Medical Genetics Part A, May 8, 2013 Review Article

9 Development of the Human Aortic Arch System Captured in an Interactive Three-Dimensional Reference Model American Journal of Medical Genetics Part A, May 7, 2013 Review Article

10 Impact of age on male fertility Current Opinion in Obstetrics and Gynecology, May 14, 2013 Review Article

11 Robust evidence for five new Grave's disease risk loci from a staged genome-wide association analysis Human Molecular Genetics, May 8, 2013 Review Article

12 An Anxious Heart: Anxiety and the Onset of Cardiovascular Diseases Progress in Cardiovascular Diseases , May 1, 2013

13 Thirty years beyond discovery--Clinical trials in succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism Journal of Inherited Metabolic Disease, May 28, 2013 Review Article

14 Pulmonary hypertension: diagnosis and management British Medical Journal, April 23, 2013 Review Article

15 Outpatient parenteral antibiotic therapy: Principles and practice European Journal of Internal Medicine , April 25, 2013

16 A Novel RASA1 Mutation Causing Capillary Malformation-Arteriovenous Malformation (CM-AVM) Presenting During Pregnancy American Journal of Medical Genetics Part A, May 22, 2013 Review Article

17 Hedging, knowledge and interaction: Doctors and clients talk about medical information and client experiences in genetic counseling Patient Education and Counselling, May 20, 2013 Review Article

18 The endocrinology of exercise Internal and Emergency Medicine, March 27, 2013 Review Article
Exclusive Author Commentary

19 Walking Versus Running for Hypertension, Cholesterol, and Diabetes Mellitus Risk Reduction Arteriosclerosis, Thrombosis, and Vascular Biology, April 17, 2013

20 Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors BMC Medicine, April 25, 2013 Free full text

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Basic Science/Genetics News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Med Articles

Other Topics in Internal Medicine