Internal Medicine - Cardiology News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Articles

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1 Targeted use of heparin, heparinoids, or low-molecular-weight heparin to improve outcome after acute ischaemic stroke: an individual patient data meta-analysis of randomised controlled trials The Lancet Neurology, May 17, 2013 Evidence Based Medicine Review Article Clinical Article

2 Pacemaker or Defibrillator Surgery without Interruption of Anticoagulation New England Journal of Medicine, May 17, 2013 Evidence Based Medicine Clinical Article

3 Orthostatic Hypotension and the Risk of Congestive Heart Failure: A Meta-Analysis of Prospective Cohort Studies PLOS ONE, May 17, 2013 Evidence Based Medicine

4 The physical anthropometry, lifestyle habits and blood pressure of people presenting with a first clinical demyelinating event compared to controls: The Ausimmune study Multiple Sclerosis Journal, May 17, 2013 Clinical Article

5 Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia Human Molecular Genetics, May 17, 2013 Review Article

6 Atrial fibrillation - inflammation in disguise? Scandinavian Journal of Immunology, May 17, 2013 Review Article

7 Multidetector Computed Tomography for Coronary Stents Imaging: High-Voltage (140-kVp) Prospective ECG-Triggered Versus Standard-Voltage (120-kVp) Retrospective ECG-Gated Helical Scanning Journal of Computer Assisted Tomography, May 17, 2013 Clinical Article

8 Blood Cholesterol Trends 2001-2011 in the United States: Analysis of 105 Million Patient Records PLOS ONE, May 17, 2013 Review Article

Prior Articles

9 Comparison of In-Hospital Outcomes With Low-Dose Fibrinolytic Therapy Followed by Urgent Percutaneous Coronary Intervention Versus Percutaneous Coronary Intervention Alone for Treatment of ST-Elevation Myocardial Infarction The American Journal of Cardiology, May 16, 2013 Clinical Article

10 Usefulness of Frequent Supraventricular Extrasystoles and a High CHADS2 Score to Predict First-Time Appearance of Atrial Fibrillation The American Journal of Cardiology, May 16, 2013 Clinical Article

11 Urinary Magnesium Excretion and Risk of Hypertension Hypertension, May 16, 2013 Clinical Article

12 Depression as a non-causal variable risk marker in coronary heart disease Full Text BMC Medicine, May 16, 2013 Clinical Article

13 Depression as a risk factor for adverse outcomes in coronary heart disease Full Text BMC Medicine, May 16, 2013 Clinical Article

14 Connexin Expression Patterns in Arrhythmogenic Right Ventricular Cardiomyopathy The American Journal of Cardiology, May 16, 2013 Clinical Article

15 Frequency, Mechanisms, and Implications of Late Peri-Stent Contrast Staining: Analysis (from the HORIZONS-AMI Trial) The American Journal of Cardiology, May 16, 2013 Clinical Article

16 Evaluation of XIENCE V Everolimus-Eluting and Taxus Express2 Paclitaxel-Eluting Coronary Stents in Patients With Jailed Side Branches From the SPIRIT IV Trial at 2 Years The American Journal of Cardiology, May 16, 2013 Clinical Article

17 Relation of Pulse and Systolic and Mean Blood Pressure to Severe Renal Artery Stenosis in Patients Undergoing Concurrent Coronary and Renal Angiography The American Journal of Cardiology, May 16, 2013 Clinical Article

18 Evaluation of Circulation Disorder in Coronary Slow Flow by Fundus Fluorescein Angiography The American Journal of Cardiology, May 16, 2013 Clinical Article

19 Novel Description of the 24-Hour Circadian Rhythms of Brachial Versus Central Aortic Blood Pressure and the Impact of Blood Pressure Treatment in a Randomized Controlled Clinical Trial Hypertension, May 16, 2013 Clinical Article

20 Dapper-1 Induces Myocardial Remodeling Through Activation of Canonical Wnt Signaling in Cardiomyocytes Hypertension, May 16, 2013 Clinical Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2012

1 Walking Versus Running for Hypertension, Cholesterol, and Diabetes Mellitus Risk Reduction Arteriosclerosis, Thrombosis, and Vascular Biology, April 17, 2013

2 Renin-angiotensin system inhibitors for prevention of recurrent atrial fibrillation: a meta-analysis International Journal of Clinical Practice, April 9, 2013 Evidence Based Medicine Review Article

3 Vitamin D Levels for Preventing Acute Coronary Syndrome and Mortality: Evidence of a Non-Linear Association Journal of Clinical Endocrinology and Metabolism, March 27, 2013
Exclusive Author Commentary

4 Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial The Lancet, April 18, 2013

5 Advances in Stroke Prevention in Atrial Fibrillation: Enhanced Risk Stratification Combined With the Newer Oral Anticoagulants Clinical Cardiology, April 11, 2013 Free full text Review Article

6 Pulmonary hypertension: diagnosis and management British Medical Journal, April 23, 2013 Review Article

7 Oral Anticoagulation and Implantation of Cardiac Rhythm Management Devices: Is Heparin a Bridge Too Far? The Hellenic Journal of Cardiology, April 16, 2013 Free full text

8 Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials British Medical Journal, April 25, 2013 Evidence Based Medicine Review Article

9 B-Type Natriuretic Peptide and Prognosis in Heart Failure Patients With Preserved and Reduced Ejection Fraction JACC - Journal of the American College of Cardiology, April 3, 2013 Free full text

10 Iron deficiency in chronic heart failure: An international pooled analysis American Heart Journal, April 1, 2013

11 Outcomes of apixaban vs. warfarin by type and duration of atrial fibrillation: results from the ARISTOTLE trial European Heart Journal, April 22, 2013

12 Enalapril And Carvedilol for Preventing Chemotherapy-Induced Left Ventricular Systolic Dysfunction in Patients with Malignant Hemopathies. The OVERCOME Trial JACC - Journal of the American College of Cardiology, April 12, 2013

13 Primary Prevention of Cardiovascular Disease with a Mediterranean Diet New England Journal of Medicine, April 8, 2013 Free full text

14 Use and indications of cholestyramine and bile acid sequestrants Internal and Emergency Medicine, April 9, 2013 Review Article

15 Efficacy and safety of dabigatran etexilate and warfarin in real world patients with atrial fibrillation: A prospective nationwide cohort study JACC - Journal of the American College of Cardiology, April 15, 2013

16 Six-Minute Walk Test: An Effective and Necessary Tool in Modern Cardiac Rehabilitation The Hellenic Journal of Cardiology, April 16, 2013 Free full text Review Article

17 L-Carnitine in the Secondary Prevention of Cardiovascular Disease: Systematic Review and Meta-analysis Mayo Clinic Proceedings, April 19, 2013 Evidence Based Medicine Review Article

18 Role of Vitamin D in Cardiometabolic Diseases Experimental Diabetes Research, March 5, 2013 Free full text Review Article

19 Practical use of dabigatran etexilate for stroke prevention in atrial fibrillation International Journal of Clinical Practice, April 9, 2013

20 Effect of seven-day atorvastatin pretreatment on the incidence of periprocedural myocardial infarction following percutaneous coronary intervention in patients receiving long-term statin therapy. A randomized study International Journal of Cardiology, April 19, 2013

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Cardiology News & Articles

Articles

Prior Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine