Internal Medicine - Rheumatology News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Latest (41) Full Text Articles (143) Focus on Depression

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1 A randomised, double-blind, multicentre, parallel-group, prospective study comparing the pharmacokinetics, safety, and efficacy of CT-P13 and innovator infliximab in patients with ankylosing spondylitis: the PLANETAS study Annals of Rheumatic Diseases, May 21, 2013 Clinical Article

2 Efficacy and safety of adalimumab in patients with non-radiographic axial spondyloarthritis: results of a randomised placebo-controlled trial (ABILITY-1) Annals of Rheumatic Diseases, May 21, 2013 Clinical Article

3 Muscle cell-derived factors inhibit inflammatory stimuli-induced damage in hMSC-derived chondrocytes Osteoarthritis and Cartilage , May 21, 2013 Review Article

4 Gradual strenuous running regimen predisposes to osteoarthritis due to cartilage cell death and altered levels of glycosaminoglycans Osteoarthritis and Cartilage , May 21, 2013 Review Article

5 Hypoxia-Inducible Factor: A Potential Therapeutic Target for Rheumatoid Arthritis Current Drug Targets, May 21, 2013 Clinical Article

6 MicroRNA-488 regulates zinc transporter SLC39A8/ZIP8 during pathogenesis of osteoarthritis Full Text Journal of Biomedical Science, May 21, 2013

7 Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster analysis Annals of Rheumatic Diseases, May 21, 2013 Clinical Article

8 Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS) Annals of Rheumatic Diseases, May 21, 2013 Review Article

9 The concentration of anticitrullinated protein antibodies in serum and synovial fluid in relation to total immunoglobulin concentrations Annals of Rheumatic Diseases, May 21, 2013 Review Article

10 Ambient air pollution exposures and risk of rheumatoid arthritis: results from the Swedish EIRA case-control study Annals of Rheumatic Diseases, May 21, 2013 Clinical Article

11 Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2 Annals of Rheumatic Diseases, May 21, 2013 Review Article

12 Patients needs and expectations with regard to rheumatology nursing care: results of multicentre focus group interviews Annals of Rheumatic Diseases, May 21, 2013 Clinical Article

13 Induction therapy with adalimumab plus methotrexate for 24 weeks followed by methotrexate monotherapy up to week 48 versus methotrexate therapy alone for DMARD-naive patients with early rheumatoid arthritis: HIT HARD, an investigator-initiated study Annals of Rheumatic Diseases, May 21, 2013 Clinical Article

14 Co-localisation of non-cartilaginous articular pathology increases risk of cartilage loss in the tibiofemoral joint--the MOST study Annals of Rheumatic Diseases, May 21, 2013 Clinical Article

15 Microarray-based gene expression profiling in patients with cryopyrin-associated periodic syndromes defines a disease-related signature and IL-1-responsive transcripts Annals of Rheumatic Diseases, May 21, 2013 Review Article

16 A randomised, double-blind, parallel-group study to demonstrate equivalence in efficacy and safety of CT-P13 compared with innovator infliximab when coadministered with methotrexate in patients with active rheumatoid arthritis: the PLANETRA study Annals of Rheumatic Diseases, May 21, 2013 Clinical Article

17 Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data Annals of Rheumatic Diseases, May 21, 2013 Review Article

18 A preliminary algorithm introducing immunogenicity assessment in the management of patients with RA receiving tumour necrosis factor inhibitor therapies Annals of Rheumatic Diseases, May 21, 2013 Clinical Article

19 Patient satisfaction with nursing consultations in a rheumatology outpatient clinic: a 21-month randomised controlled trial in patients with inflammatory arthritides Annals of Rheumatic Diseases, May 21, 2013 Clinical Article

20 Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment Annals of Rheumatic Diseases, May 21, 2013 Review Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Internal Medicine - Rheumatology News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine