What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.
Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.
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161 EGFR and KRAS mutational profiling in fresh non-small cell lung cancer (NSCLC) cells Journal of Cancer Research & Clinical Oncology, May 6, 2013 Clinical Article
162 New insights of P2X7 receptor signaling pathway in alveolar functions Full Text Journal of Biomedical Science, May 6, 2013
163 Cough Aerosols of Mycobacterium tuberculosis Predict New Infection American Journal of Respiratory and Critical Care Medicine, May 3, 2013 Clinical Article
164 Predictors of Objective Cough Frequency in Chronic Obstructive Pulmonary Disease American Journal of Respiratory and Critical Care Medicine, May 3, 2013 Clinical Article
165 An Official American Thoracic Society Clinical Practice Guideline: Exercise-induced Bronchoconstriction American Journal of Respiratory and Critical Care Medicine, May 3, 2013 Clinical Article
166 Alveolar nitric oxide and asthma control in mild untreated asthma The Journal of Allergy and Clinical Immunology, May 3, 2013 Clinical Article
167 Intratumour variation of biomarker expression by immunohistochemistry in resectable non-small cell lung cancer European Journal of Cancer, May 3, 2013 Clinical Article
168 Twenty-five years of research on the behavioural malaise associated with influenza and the common cold Psychoneuroendocrinology, May 3, 2013 Review Article
169 Real-World Effectiveness of Systemic Agents Approved for Advanced Non-Small Cell Lung Cancer: A SEER-Medicare Analysis Full Text The Oncologist, May 3, 2013 Clinical Article
170 Non-steroidal anti-inflammatory drug hypersensitivity in adults and the factors associated with asthma Respiratory Medicine, May 3, 2013 Clinical Article
171 CD8+ T cells characterize early smoking-related airway pathology in patients with asthma Respiratory Medicine, May 3, 2013 Clinical Article
172 Role of ultrasound-guided transbronchial biopsy in the diagnosis of peripheral pulmonary lesions Lung Cancer, May 3, 2013 Clinical Article
173 Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549 lung cancer cells Full Text Molecular Cancer, May 3, 2013 Clinical Article
174 A Systematic Review of the Association between Pulmonary Tuberculosis and the Development of Chronic Airflow Obstruction in Adults Respiration, May 3, 2013 Clinical Article
175 Serotype Distribution of Streptococcus pneumoniae Causing Parapneumonic Empyema in Turkey Clinical and Vaccine Immunology, May 3, 2013 Review Article
176 The Neutrophil in Chronic Obstructive Pulmonary Disease American Journal of Respiratory Cell and Molecular Biology, May 3, 2013 Clinical Article
177 Molecular characterization of carbapenem-resistant Klebsiella pneumoniae in a tertiary university hospital in Turkey Journal of Hospital Infection, May 3, 2013 Clinical Article
178 Independent of ErbB1 gene copy number, EGF stimulates migration but is not associated with cell proliferation in non-small cell lung cancer Cancer Cell International, May 3, 2013 Clinical Article
179 Genetic polymorphisms and associated susceptibility to asthma Full Text International Journal of General Medicine, May 3, 2013
180 Reversal of Global CD4+ Subset Dysfunction Is Associated with Spontaneous Clinical Resolution of Pulmonary Sarcoidosis The Journal of Immunology, May 3, 2013 Clinical Article
Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).
Read the article summaryResearchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.
Read the article summaryResearchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.
Read the article summary1 Regular treatment with salmeterol and inhaled steroids for chronic asthma: serious adverse events Cochrane Reviews, April 2, 2013 Review Article
2 Pulmonary hypertension: diagnosis and management British Medical Journal, April 23, 2013 Review Article
3 Three phenotypes of adult-onset asthma Allergy, April 19, 2013 Review Article
4 Cardiovascular events after clarithromycin use in lower respiratory tract infections: analysis of two prospective cohort studies British Medical Journal, April 10, 2013 Free full text
5 Does aspirin use prevent acute coronary syndrome in patients with pneumonia: multicenter prospective randomized trial Coronary Artery Disease, April 12, 2013
6 Effect of Azithromycin Maintenance Treatment on Infectious Exacerbations Among Patients With Non–Cystic Fibrosis Bronchiectasis: The BAT Randomized Controlled Trial JAMA, March 27, 2013 Evidence Based Medicine
7 Peripheral lung function in patients with stable and unstable asthma The Journal of Allergy and Clinical Immunology, April 8, 2013
8 Invasive mechanical ventilation in acute coronary syndromes in the era of percutaneous coronary intervention European Heart Journal: Acute Cardiovascular Care, April 16, 2013
9 Inhaled corticosteroids for subacute and chronic cough in adults Cochrane Reviews, April 11, 2013
10 Lack of a relation between serum 25(OH)D concentrations and asthma in adolescents American Journal of Clinical Nutrition, April 18, 2013
11 Asthma outcomes and costs of therapy with extrafine beclomethasone and fluticasone The Journal of Allergy and Clinical Immunology, April 16, 2013
12 Predictors of early dyspnoea relief in acute heart failure and the association with 30-day outcomes: findings from ASCEND-HF European Journal of Heart Failure, March 27, 2013
13 Sublingual Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and Asthma: A Systematic Review JAMA, March 27, 2013 Evidence Based Medicine
14 Application of appropriateness criteria for hospitalization in COPD exacerbation Internal and Emergency Medicine, April 5, 2013
15 Ciclesonide versus other inhaled corticosteroids for chronic asthma in children Cochrane Reviews, March 7, 2013 Review Article
16 Effect of Long-term, Low-Dose Erythromycin on Pulmonary Exacerbations Among Patients With Non–Cystic Fibrosis Bronchiectasis: The BLESS Randomized Controlled Trial JAMA, March 27, 2013 Evidence Based Medicine
17 Identification of patients with low-risk pulmonary embolism suitable for outpatient treatment using the pulmonary embolism severity index (PESI) Irish Journal of Medical Science, March 26, 2013
18 Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: meta-analysis of randomised controlled trials European Journal of Clinical Microbiology & Infectious Diseases, April 10, 2013 Evidence Based Medicine
19 Characteristics of Lung Cancers Detected by Computer Tomography Screening in the Randomized NELSON Trial American Journal of Respiratory and Critical Care Medicine, April 18, 2013
20 Combination therapy in the management of pulmonary arterial hypertension International Journal of Clinical Practice, April 15, 2013 Review Article
Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more
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