Internal Medicine - Pulmonology News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

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61 New dilemmas in small-cell lung cancer TNM clinical staging Full Text OncoTargets and Therapy, May 17, 2013 Clinical Article

62 Lipopolysaccharide Induces Endoplasmic Store Ca2+-Dependent Inflammatory Responses in Lung Microvessels PLOS ONE, May 17, 2013 Review Article

63 Plasma 25-hydroxyvitamin D associated with pulmonary function in Canadian adults with excess adiposity American Journal of Clinical Nutrition, May 16, 2013 Clinical Article

64 Anti-viral agents: potential utility in exacerbations of asthma Current Opinion in Pharmacology , May 16, 2013 Review Article

65 Effect of Travel on Influenza Epidemiology Full Text Emerging Infectious Diseases, May 16, 2013 Clinical Guideline

66 Curcumin Nanoparticles Ameliorate ICAM-1 Expression in TNF-alpha-Treated Lung Epithelial Cells through p47 phox and MAPKs/AP-1 Pathways PLOS ONE, May 16, 2013 Review Article

67 The Coexistence of Asthma and Chronic Obstructive Pulmonary Disease (COPD): Prevalence and Risk Factors in Young, Middle-aged and Elderly People from the General Population PLOS ONE, May 16, 2013 Clinical Article

68 Lymphocyte subpopulations in active tuberculosis: association with disease severity and the QFT-GIT assay The International Journal of Tuberculosis and Lung Disease, May 16, 2013 Clinical Article

69 Idiopathic pulmonary fibrosis as a prognostic factor in non-small cell lung cancer International Journal of Clinical Oncology, May 16, 2013 Review Article

70 Epigenetic Therapy in Lung Cancer Frontiers in Oncology, May 16, 2013 Review Article

71 Factors Associated with elevated Pulmonary Arterial Pressure Levels on the Echocardiographic Assessment in Patients with Prior Pulmonary Embolism Thrombosis Research, May 16, 2013 Review Article

72 Improvement of right ventricular dysfunction after pulmonary endarterectomy in patients with chronic thromboembolic pulmonary hypertension: Utility of echocardiography to demonstrate restoration of the right ventricle during 2-year follow-up Thrombosis Research, May 16, 2013 Evidence Based Medicine

73 Treatment of Idiopathic Pulmonary Fibrosis With Ambrisentan - A Parallel, Randomized Trial Annals of Internal Medicine, May 15, 2013 Clinical Article

74 Predicting steroid responsiveness in patients with asthma using exhaled breath profiling Clinical & Experimental Allergy, May 15, 2013 Clinical Article

75 Increased IgG but normal IgA anti-pneumococcal protein antibodies in lung of HIV-infected adults Vaccine , May 15, 2013 Clinical Article

76 High dose urokinase against massive pulmonary embolism in nephrotic syndrome Blood Coagulation & Fibrinolysis, May 15, 2013 Clinical Article

77 Pulmonary actinomycosis during the first decade of 21st century: cases of 94 patients Full Text BMC Infectious Diseases, May 15, 2013 Review Article Clinical Article

78 Associations Between Vitamin D and Self-Reported Respiratory Disease in Older People from a Nationally Representative Population Survey Journal of the American Geriatrics Society, May 14, 2013 Clinical Article

79 Non-invasive ventilation for cystic fibrosis Cochrane Reviews, May 14, 2013 Evidence Based Medicine Clinical Article

80 Distribution of health-related social surplus in pharmaceuticals: an estimation of consumer and producer surplus in the management of high blood lipids and COPD The European Journal of Health Economics, May 14, 2013 Review Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2012

1 Regular treatment with salmeterol and inhaled steroids for chronic asthma: serious adverse events Cochrane Reviews, April 2, 2013 Review Article

2 Pulmonary hypertension: diagnosis and management British Medical Journal, April 23, 2013 Review Article

3 Three phenotypes of adult-onset asthma Allergy, April 19, 2013 Review Article

4 Cardiovascular events after clarithromycin use in lower respiratory tract infections: analysis of two prospective cohort studies British Medical Journal, April 10, 2013 Free full text

5 Does aspirin use prevent acute coronary syndrome in patients with pneumonia: multicenter prospective randomized trial Coronary Artery Disease, April 12, 2013

6 Effect of Azithromycin Maintenance Treatment on Infectious Exacerbations Among Patients With Non–Cystic Fibrosis Bronchiectasis: The BAT Randomized Controlled Trial JAMA, March 27, 2013 Evidence Based Medicine

7 Peripheral lung function in patients with stable and unstable asthma The Journal of Allergy and Clinical Immunology, April 8, 2013

8 Invasive mechanical ventilation in acute coronary syndromes in the era of percutaneous coronary intervention European Heart Journal: Acute Cardiovascular Care, April 16, 2013

9 Inhaled corticosteroids for subacute and chronic cough in adults Cochrane Reviews, April 11, 2013

10 Lack of a relation between serum 25(OH)D concentrations and asthma in adolescents American Journal of Clinical Nutrition, April 18, 2013

11 Asthma outcomes and costs of therapy with extrafine beclomethasone and fluticasone The Journal of Allergy and Clinical Immunology, April 16, 2013

12 Predictors of early dyspnoea relief in acute heart failure and the association with 30-day outcomes: findings from ASCEND-HF European Journal of Heart Failure, March 27, 2013

13 Sublingual Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and Asthma: A Systematic Review JAMA, March 27, 2013 Evidence Based Medicine

14 Application of appropriateness criteria for hospitalization in COPD exacerbation Internal and Emergency Medicine, April 5, 2013

15 Ciclesonide versus other inhaled corticosteroids for chronic asthma in children Cochrane Reviews, March 7, 2013 Review Article

16 Effect of Long-term, Low-Dose Erythromycin on Pulmonary Exacerbations Among Patients With Non–Cystic Fibrosis Bronchiectasis: The BLESS Randomized Controlled Trial JAMA, March 27, 2013 Evidence Based Medicine

17 Identification of patients with low-risk pulmonary embolism suitable for outpatient treatment using the pulmonary embolism severity index (PESI) Irish Journal of Medical Science, March 26, 2013

18 Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: meta-analysis of randomised controlled trials European Journal of Clinical Microbiology & Infectious Diseases, April 10, 2013 Evidence Based Medicine

19 Characteristics of Lung Cancers Detected by Computer Tomography Screening in the Randomized NELSON Trial American Journal of Respiratory and Critical Care Medicine, April 18, 2013

20 Combination therapy in the management of pulmonary arterial hypertension International Journal of Clinical Practice, April 15, 2013 Review Article

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Pulmonology News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine