Internal Medicine - Nephrology/Urology News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Articles

Latest (19) Full Text Articles (441) Focus on Heart Failure

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

141 The histology of prostate tissue following prostatic artery embolization for the treatment of benign prostatic hyperplasia Full Text International Braz J Urol, May 8, 2013 Clinical Article

142 Prognostic impact of LDH levels in patients with relapsed/refractory seminoma Journal of Cancer Research & Clinical Oncology, May 8, 2013 Clinical Article

143 New Paradigms in Microtubule-Mediated Endocrine Signaling in Prostate Cancer Molecular Cancer Therapeutics, May 8, 2013 Clinical Article

144 Removing salt sachets from ward meal-trays does not affect patients' nutritional intake Journal of Renal Care, May 8, 2013 Clinical Article

145 Deterioration of continence after tot when the follow-up is extended: results from a randomised controlled study Urology Times, May 8, 2013 Clinical Article

146 Worsening urinary storage symptoms following sling surgery in stress-incontinent women: incidence, associations, and management Urology Times, May 8, 2013 Clinical Article

147 Targeted therapies and the treatment of non-clear cell renal cell carcinoma Annals of Oncology, May 8, 2013 Clinical Article

148 Ultrasonography in prostate cancer: current roles and potential applications in radiorecurrent disease World Journal of Urology, May 7, 2013 Clinical Article

149 Platinum-Based Chemotherapy for Variant Castrate-Resistant Prostate Cancer Clinical Cancer Research, May 7, 2013 Clinical Article

150 Novel HSP90 Inhibitor NVP-HSP990 Targets Cell-Cycle Regulators to Ablate Olig2-Positive Glioma Tumor–Initiating Cells Cancer Research, May 7, 2013 Clinical Article

151 PSA screening and deaths from prostate cancer after diagnosis—a population based analysis The Prostate, May 7, 2013 Clinical Article

152 Men with prostate cancer make positive dietary changes following diagnosis and treatment Cancer Causes and Control, May 7, 2013 Clinical Article

153 High CRP values predict poor survival in patients with penile cancer Full Text BMC Cancer, May 7, 2013 Clinical Article

154 A phase 1 study of a chimeric monoclonal antibody against interleukin-6, siltuximab, combined with docetaxel in patients with metastatic castration-resistant prostate cancer Investigational New Drugs, May 7, 2013 Clinical Article

155 Sperm banking is of key importance in patients with prostate cancer Fertility and Sterility, May 7, 2013 Clinical Article

156 Testosterone replacement therapy does not promote priapism in hypogonadal men with sickle cell disease: 12-month safety report Journal of Andrology, May 7, 2013 Clinical Article

157 Outcome of female urethral reconstruction: a 12-year experience World Journal of Urology, May 7, 2013 Clinical Article
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158 Risk factors for male lower urinary tract symptoms: the role of metabolic syndrome and androgenetic alopecia in a Latin American population Urology, May 7, 2013 Clinical Article

159 The relationship between depressive symptoms and erythropoietin resistance in stable hemodialysis patients with adequate iron stores The International Journal of Artificial Organs, May 7, 2013 Review Article

160 Impact of the association between elevated oestradiol and low testosterone levels on erectile dysfunction severity Asian Journal of Andrology, May 7, 2013 Clinical Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2012

1 Statin use and risk of prostate cancer and high-grade prostate cancer: results from the REDUCE study Prostate Cancer & Prostatic Diseases, April 11, 2013

2 Antihypertensive Efficacy of Olmesartan Medoxomil and Ramipril in Elderly Patients with Mild to Moderate Hypertension Grouped According to Renal Function Status High Blood Pressure & Cardiovascular Prevention, April 16, 2013

3 Lifetime Incidence of CKD Stages 3-5 in the United States American Journal of Kidney Diseases, April 9, 2013

4 Detecting and controlling diabetic nephropathy: What do we know? Cleveland Clinic Journal of Medicine, April 3, 2013 Free full text

5 Strategy for detection of prostate cancer based on relation between prostate specific antigen at age 40-55 and long term risk of metastasis: case-control study British Medical Journal, April 23, 2013

6 Effective elimination of dabigatran by haemodialysis Thrombosis and Haemostasis, April 12, 2013

7 Chlorthalidone Versus Hydrochlorothiazide for the Treatment of Hypertension in Older Adults A Population-Based Cohort Study Annals of Internal Medicine, March 19, 2013

8 Kidney Cancer and Diabetes Mellitus: A Population-Based Case-Control Study in Taiwan Annals, Academy of Medicine, Singapore, April 4, 2013 Free full text

9 Outcomes Associated With Microalbuminuria Effect Modification by Chronic Kidney Disease JACC - Journal of the American College of Cardiology, April 12, 2013 Free full text

10 Managing the difficult penile prosthesis patient The Journal of Sexual Medicine, April 8, 2013

11 Blood Urea Nitrogen/Creatinine Ratio Identifies a High-Risk but Potentially Reversible Form of Renal Dysfunction in Patients With Decompensated Heart Failure Circulation: Heart Failure, March 26, 2013 Review Article

12 Mortality Predictability of Body Size and Muscle Mass Surrogates in Asian vs White and African American Hemodialysis Patients Mayo Clinic Proceedings, April 9, 2013 Evidence Based Medicine

13 An open-label, long-term evaluation of the safety, efficacy and tolerability of avanafil in male patients with mild to severe erectile dysfunction International Journal of Clinical Practice, April 9, 2013

14 Current State of Endovascular Treatment for Vasculogenic Erectile Dysfunction Current Cardiology Reports, April 8, 2013

15 Type 2 Translational Research for CKD Clinical Journal of the American Society of Nephrology, April 29, 2013

16 Frequency of Acute Kidney Injury Following Intravenous Contrast Medium Administration: A Systematic Review and Meta-Analysis Radiology, March 29, 2013 Evidence Based Medicine Review Article

17 Canadian Society of Nephrology Guidelines for the Management of Patients With ESRD Treated With Intensive Hemodialysis American Journal of Kidney Diseases, April 9, 2013

18 Predictors of diabetic nephropathy Central European Journal of Medicine, April 23, 2013

19 Renin-Angiotensin System Blockers May Create More Risk Than Reward for Sodium-Depleted Cardiovascular Patients With High Plasma Renin Levels American Journal of Hypertension, April 8, 2013 Free full text

20 Non-steroidal anti-inflammatory drugs and chronic kidney disease progression: a systematic review Family Practice, January 10, 2013 Evidence Based Medicine
Exclusive Author Commentary

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Nephrology/Urology News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine