Internal Medicine - Infectious Disease News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Articles

Latest (35) Full Text Articles (1098) Focus on Depression

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

81 Fine Analysis of Genetic Diversity of the tpr Gene Family among Treponemal Species, Subspecies and Strains Full Text PLoS Neglected Tropical Diseases, May 17, 2013 Review Article

82 Rapid, Simple and Sensitive Detection of Q Fever by Loop-Mediated Isothermal Amplification of the htpAB Gene Full Text PLoS Neglected Tropical Diseases, May 17, 2013 Clinical Article

83 Disruption of Aedes aegypti Olfactory System Development through Chitosan/siRNA Nanoparticle Targeting of semaphorin-1α Full Text PLoS Neglected Tropical Diseases, May 17, 2013 Review Article

84 The Cellular Decapping Activators LSm1, Pat1, and Dhh1 Control the Ratio of Subgenomic to Genomic Flock House Virus RNAs Journal of Virology, May 17, 2013 Review Article

85 Nuclear Transport of Epstein-Barr Virus DNA Polymerase Is Dependent on the BMRF1 Polymerase Processivity Factor and Molecular Chaperone Hsp90 Journal of Virology, May 17, 2013 Review Article

86 Generation of Genetically Stable Recombinant Rotaviruses Containing Novel Genome Rearrangements and Heterologous Sequences by Reverse Genetics Journal of Virology, May 17, 2013 Review Article

87 Deciphering the Mechanism of Defective Interfering RNA (DI RNA) Biogenesis Reveals That a Viral Protein and the DI RNA Act Antagonistically in Virus Infection Journal of Virology, May 17, 2013 Review Article

88 Tyrosine 132 Phosphorylation of Influenza A Virus M1 Protein Is Crucial for Virus Replication by Controlling the Nuclear Import of M1 Journal of Virology, May 17, 2013 Review Article

89 The Transmembrane Domain of the Adenovirus E3/19K Protein Acts as an Endoplasmic Reticulum Retention Signal and Contributes to Intracellular Sequestration of Major Histocompatibility Complex Class I Molecules Journal of Virology, May 17, 2013 Review Article

90 Isolation and Characterization of Current Human Coronavirus Strains in Primary Human Epithelial Cell Cultures Reveal Differences in Target Cell Tropism Journal of Virology, May 17, 2013 Review Article

91 The Transcriptome of the Baculovirus Autographa californica Multiple Nucleopolyhedrovirus in Trichoplusia ni Cells Journal of Virology, May 17, 2013 Review Article

92 Structure-Function Analysis of Severe Acute Respiratory Syndrome Coronavirus RNA Cap Guanine-N7-Methyltransferase Journal of Virology, May 17, 2013 Review Article

93 Rotavirus Prevents the Expression of Host Responses by Blocking the Nucleocytoplasmic Transport of Polyadenylated mRNAs Journal of Virology, May 17, 2013 Review Article

94 The Receptor Attachment Function of Measles Virus Hemagglutinin Can Be Replaced with an Autonomous Protein That Binds Her2/neu While Maintaining Its Fusion-Helper Function Journal of Virology, May 17, 2013 Review Article

95 TMPRSS2 Activates the Human Coronavirus 229E for Cathepsin-Independent Host Cell Entry and Is Expressed in Viral Target Cells in the Respiratory Epithelium Journal of Virology, May 17, 2013 Review Article

96 Identification and Characterization of Genetically Divergent Members of the Newly Established Family Mesoniviridae Journal of Virology, May 17, 2013 Review Article

97 Role of E1B55K in E4orf6/E1B55K E3 Ligase Complexes Formed by Different Human Adenovirus Serotypes Journal of Virology, May 17, 2013 Review Article

98 HIV-1 Gag Associates with Specific Uropod-Directed Microdomains in a Manner Dependent on Its MA Highly Basic Region Journal of Virology, May 17, 2013 Review Article

99 Recombination within the Pandemic Norovirus GII.4 Lineage Journal of Virology, May 17, 2013 Review Article

100 Kaposi's Sarcoma-Associated Herpesvirus Induces Rapid Release of Angiopoietin-2 from Endothelial Cells Journal of Virology, May 17, 2013 Review Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2012

1 Infective Endocarditis New England Journal of Medicine, April 12, 2013

2 Echocardiography in pericardial diseases: new developments Heart Failure Reviews, April 19, 2013

3 Varicella Zoster Virus-Specific Immune Responses to a Herpes Zoster Vaccine in Elderly Recipients With Major Depression and the Impact of Antidepressant Medications Clinical Infectious Diseases, March 26, 2013

4 Effect of adequate single-drug versus combination antimicrobial therapy on mortality in Pseudomonas aeruginosa bloodstream infections. A post hoc analysis of a prospective cohort Clinical Infectious Diseases, April 17, 2013

5 Antibiotics for brain abscesses in people with cyanotic congenital heart disease Cochrane Reviews, April 3, 2013

6 Update on polymyalgia rheumatica European Journal of Internal Medicine , April 12, 2013

7 Fungal rhinosinusitis: what every allergist should know Clinical & Experimental Allergy, March 27, 2013

8 Infectious Complications Following Transrectal Ultrasound-Guided Prostate Biopsy: New Challenges in the Era of Multidrug-Resistant Escherichia coli Clinical Infectious Diseases, April 18, 2013

9 Interventions to improve professional adherence to guidelines for prevention of device-related infections Cochrane Reviews, April 4, 2013 Evidence Based Medicine

10 Combination Antifungal Therapy for Cryptococcal Meningitis New England Journal of Medicine, April 8, 2013

11 Cardiovascular events after clarithromycin use in lower respiratory tract infections: analysis of two prospective cohort studies British Medical Journal, April 10, 2013 Free full text

12 Proton Pump Inhibitor Use and the Risk of Small Intestinal Bacterial Overgrowth: A Meta-analysis Clinical Gastroenterology and Hepatology , April 23, 2013

13 Acute pneumonia and the cardiovascular system The Lancet, March 12, 2013 Review Article

14 Carbapenem-resistant Enterobacteriaceae: A menace to our most vulnerable patients Cleveland Clinic Journal of Medicine, April 11, 2013 Free full text

15 Chinese medicinal herbs for influenza Cochrane Reviews, April 11, 2013

16 Continuous versus intermittent infusions of antibiotics for the treatment of severe acute infections Cochrane Reviews, March 29, 2013 Review Article

17 Incidence of Campylobacter and Salmonella Infections Following First Prescription for PPI: A Cohort Study Using Routine Data The American Journal of Gastroenterology, April 17, 2013

18 Quadruple therapy for eradication of Helicobacter pylori World Journal of Gastroenterology, February 21, 2013 Free full text

19 Diagnosing tuberculous meningitis ? have we made any progress? Tropical Medicine & International Health, March 27, 2013 Review Article

20 Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: meta-analysis of randomised controlled trials European Journal of Clinical Microbiology & Infectious Diseases, April 10, 2013 Evidence Based Medicine

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Infectious Disease News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine