Internal Medicine - Infectious Disease News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Articles

Latest (59) Full Text Articles (1098) Focus on Substance Abuse

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

61 A Risk for Hepatocellular Carcinoma Persists Long-term After Sustained Virologic Response in Patients With Hepatitis C-Associated Liver Cirrhosis Clinical Infectious Diseases, May 16, 2013 Clinical Article

62 Tapeworm Infection of the Brain JAMA, May 16, 2013 Evidence Based Medicine Review Article Clinical Article

63 Small RNAs: a new frontier in mosquito biology Trends in Parasitology, May 16, 2013 Review Article

64 Effect of Travel on Influenza Epidemiology Full Text Emerging Infectious Diseases, May 16, 2013 Clinical Guideline

65 New Delhi Metallo-β-Lactamase-producing Enterobacteriaceae, United States Full Text Emerging Infectious Diseases, May 16, 2013 Review Article

66 Haemophilus influenzae Serotype a Invasive Disease, Alaska, USA, 1983-2011 Full Text Emerging Infectious Diseases, May 16, 2013 Review Article

67 Ten-year mortality trends among persons diagnosed with HIV infection in England and Wales in the era of antiretroviral therapy: AIDS remains a silent killer HIV Medicine, May 16, 2013 Clinical Article

68 The Staphylococcal Toxin Panton-Valentine Leukocidin Targets Human C5a Receptors Cell Host & Microbe, May 16, 2013 Review Article

69 Induction of Bone Loss by Pathobiont-Mediated Nod1 Signaling in the Oral Cavity Cell Host & Microbe, May 16, 2013 Review Article

70 Malaria-Infected Erythrocyte-Derived Microvesicles Mediate Cellular Communication within the Parasite Population and with the Host Immune System Cell Host & Microbe, May 16, 2013 Review Article

71 The Shigella OspC3 Effector Inhibits Caspase-4, Antagonizes Inflammatory Cell Death, and Promotes Epithelial Infection Cell Host & Microbe, May 16, 2013 Review Article

72 The Mtb Proteome Library: A Resource of Assays to Quantify the Complete Proteome of Mycobacterium tuberculosis Cell Host & Microbe, May 16, 2013 Review Article

73 The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling Cell Host & Microbe, May 16, 2013 Review Article

74 Intravenous anidulafungin followed optionally by oral voriconazole for the treatment of candidemia in Asian patients: results from an open-label Phase III trial Full Text BMC Infectious Diseases, May 16, 2013 Clinical Article

75 Analysis of Antiviral Response in Human Epithelial Cells Infected with Hepatitis E Virus PLOS ONE, May 16, 2013 Evidence Based Medicine

76 Resistance-associated amino acid variants associated with boceprevir plus pegylated interferon-α2b and ribavirin in patients with chronic hepatitis C in the SPRINT-1 trial Antiviral Therapy , May 16, 2013 Clinical Article

77 Early diagnosis and treatment of HIV infection: magnitude of benefit on short-term mortality is greatest in older adults Age and Aging, May 16, 2013 Clinical Article

78 Rift Valley Fever Virus Clearance and Protection from Neurologic Disease Are Dependent on CD4+ T Cell and Virus-Specific Antibody Responses Journal of Virology, May 16, 2013 Review Article

79 Lymphocyte subpopulations in active tuberculosis: association with disease severity and the QFT-GIT assay The International Journal of Tuberculosis and Lung Disease, May 16, 2013 Clinical Article

80 Detection of Clostridium difficile toxins A, B and binary toxin with slow off-rate modified aptamers Diagnostic Microbiology and Infectious Disease, May 16, 2013 Review Article

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2012

1 Infective Endocarditis New England Journal of Medicine, April 12, 2013

2 Echocardiography in pericardial diseases: new developments Heart Failure Reviews, April 19, 2013

3 Varicella Zoster Virus-Specific Immune Responses to a Herpes Zoster Vaccine in Elderly Recipients With Major Depression and the Impact of Antidepressant Medications Clinical Infectious Diseases, March 26, 2013

4 Effect of adequate single-drug versus combination antimicrobial therapy on mortality in Pseudomonas aeruginosa bloodstream infections. A post hoc analysis of a prospective cohort Clinical Infectious Diseases, April 17, 2013

5 Antibiotics for brain abscesses in people with cyanotic congenital heart disease Cochrane Reviews, April 3, 2013

6 Update on polymyalgia rheumatica European Journal of Internal Medicine , April 12, 2013

7 Fungal rhinosinusitis: what every allergist should know Clinical & Experimental Allergy, March 27, 2013

8 Infectious Complications Following Transrectal Ultrasound-Guided Prostate Biopsy: New Challenges in the Era of Multidrug-Resistant Escherichia coli Clinical Infectious Diseases, April 18, 2013

9 Interventions to improve professional adherence to guidelines for prevention of device-related infections Cochrane Reviews, April 4, 2013 Evidence Based Medicine

10 Combination Antifungal Therapy for Cryptococcal Meningitis New England Journal of Medicine, April 8, 2013

11 Cardiovascular events after clarithromycin use in lower respiratory tract infections: analysis of two prospective cohort studies British Medical Journal, April 10, 2013 Free full text

12 Proton Pump Inhibitor Use and the Risk of Small Intestinal Bacterial Overgrowth: A Meta-analysis Clinical Gastroenterology and Hepatology , April 23, 2013

13 Acute pneumonia and the cardiovascular system The Lancet, March 12, 2013 Review Article

14 Carbapenem-resistant Enterobacteriaceae: A menace to our most vulnerable patients Cleveland Clinic Journal of Medicine, April 11, 2013 Free full text

15 Chinese medicinal herbs for influenza Cochrane Reviews, April 11, 2013

16 Continuous versus intermittent infusions of antibiotics for the treatment of severe acute infections Cochrane Reviews, March 29, 2013 Review Article

17 Incidence of Campylobacter and Salmonella Infections Following First Prescription for PPI: A Cohort Study Using Routine Data The American Journal of Gastroenterology, April 17, 2013

18 Quadruple therapy for eradication of Helicobacter pylori World Journal of Gastroenterology, February 21, 2013 Free full text

19 Diagnosing tuberculous meningitis ? have we made any progress? Tropical Medicine & International Health, March 27, 2013 Review Article

20 Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: meta-analysis of randomised controlled trials European Journal of Clinical Microbiology & Infectious Diseases, April 10, 2013 Evidence Based Medicine

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine - Infectious Disease News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine