Internal Medicine News & Articles

What makes MDLinx Internal Medicine different from all the other primary care literature reviews? Our team of medical editors read over 2,000 medical journals every day so you can stay current in less than 5 minutes! They sort, rank and summarize every article that will impact your daily practice. They even mark which articles are available in free full text, which are clinical or evidence-based, and which have MDLinx Exclusive Author Commentary from the people who actually performed the research.

Also on this page you’ll see bonus content from our physician editor, D. Scott Cunningham, MD, PhD, in the form of his top highlights you can’t miss, along with clinical pearls from The Smartest Internist, a quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education.

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Latest (257) Full Text Articles (9654) Focus on Substance Abuse

Ranked, sorted, and summarized by MDLinx editors from the latest literature

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41 Status Epilepticus and Semi-Reversible Cranial Magnetic Resonance Imaging Lesions: A Case Report Full Text Journal of Neurological Sciences (Turkish), October 8, 2012

42 Deletion of the TNFAIP3/A20 gene detected by FICTION analysis in classical Hodgkin lymphoma Full Text BMC Cancer, October 8, 2012

43 Multiplicative synergistic risk of hepatocellular carcinoma development among hepatitis B and C co-infected subjects in HBV endemic area: a community-based cohort study Full Text BMC Cancer, October 8, 2012

44 Outcome Comparison of 600- and 300-mg Loading Doses of Clopidogrel in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Full Text JACC - Journal of the American College of Cardiology, October 7, 2012 Original Publication Date: October 6, 2011 Clinical Article

45 Sex Hormone-Binding Globulin, But Not Testosterone, Is Associated Prospectively and Independently With Incident Metabolic Syndrome in Men: The Framingham Heart Study Full Text Diabetes Care, October 7, 2012 Original Publication Date: October 6, 2011

46 Left Atrial Compression and the Mechanism of Exercise Impairment in Patients With a Large Hiatal Hernia Full Text JACC - Journal of the American College of Cardiology, October 7, 2012 Original Publication Date: October 6, 2011

47 Left Atrial Contractile Function Following a Successful Modified Maze Procedure at Surgery and the Risk for Subsequent Thromboembolic Stroke Full Text JACC - Journal of the American College of Cardiology, October 7, 2012 Original Publication Date: October 6, 2011

48 Chronic kidney disease and risk for presenting with acute myocardial infarction versus stable exertional angina in adults with coronary heart disease Full Text JACC - Journal of the American College of Cardiology, October 7, 2012 Original Publication Date: October 6, 2011

49 Conformational change in coronary artery structure assessed by optical coherence tomography in patients with vasospastic angina Full Text JACC - Journal of the American College of Cardiology, October 7, 2012 Original Publication Date: October 6, 2011

50 Impact of the Everolimus-Eluting Stent on Stent Thrombosis: A Meta-Analysis of 13 Randomized Trials Full Text JACC - Journal of the American College of Cardiology, October 7, 2012 Original Publication Date: October 6, 2011 Evidence Based Medicine Clinical Article

51 SYNTAX score and Clinical SYNTAX score as predictors of very long-term clinical outcomes in patients undergoing percutaneous coronary interventions: a substudy of SIRolimus-eluting stent compared with pacliTAXel-eluting stent for coronary revascularization (SIRTAX) trial Full Text European Heart Journal, October 7, 2012 Original Publication Date: October 6, 2011 Clinical Article

52 Biventricular pacing: current trends and future strategies Full Text European Heart Journal, October 7, 2012 Original Publication Date: October 6, 2011

53 Long-Term Metabolic and Immunological Follow-Up of Nonimmunosuppressed Patients With Type 1 Diabetes Treated With Microencapsulated Islet Allografts Full Text Diabetes Care, October 7, 2012 Original Publication Date: October 6, 2011

54 Diabetes Antibody Standardization Program: First evaluation of assays for autoantibodies to IA-2{beta} Full Text Diabetes Care, October 7, 2012 Original Publication Date: October 6, 2011

55 Therapeutic perspectives in hypertension: novel means for renin–angiotensin-aldosterone system modulation and emerging device-based approaches Full Text European Heart Journal, October 7, 2012 Original Publication Date: October 6, 2011

56 The impact of the coronary collateral circulation on mortality: a meta-analysis Full Text European Heart Journal, October 7, 2012 Original Publication Date: October 6, 2011 Evidence Based Medicine

57 Coronary β2-adrenoreceptors mediate endothelium-dependent vasoreactivity in humans: novel insights from an in vivo intravascular ultrasound study Full Text European Heart Journal, October 7, 2012 Original Publication Date: October 6, 2011

58 Immune-mediated epilepsies Full Text Epilepsia, October 7, 2012 Original Publication Date: May 6, 2011

59 Autoantibodies and epilepsy Full Text Epilepsia, October 7, 2012 Original Publication Date: May 6, 2011

60 Human Metapneumovirus: Lessons Learned over the First Decade Full Text Clinical Microbiology Reviews, October 7, 2012 Original Publication Date: October 6, 2011

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Clinical Pearls in Internal Medicine

Vitamin D deficiency is more common with non-Caucasian patients, and those with lower social support, no insurance, diabetes, lower activity levels, higher parathyroid hormone levels, and higher body mass indexes
Eating an early breakfast and dinner when taking PPIs can lower FSSG scores and improve GERD symptoms. (Factors leading to increased FSSG scores were female gender, inadequate sleep, lack of breakfast, antihypertensive agent non-users and dinner just before bedtime.)
No single method of contraception is contraindicated by age alone, but caution should be exercised with estrogen-containing preparations in obese women over 40

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Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Among 130 patients requiring mechanical ventilation, 107 were vitamin D-deficient (< 20 ng/ml). Of the patients who did not survive, the length of survival was shorter in the vitamin D-deficient patients (15.3 vs. 24.2 days, respectively).

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Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

Researchers at Tel-Aviv University have conducted a study to determine the value of coronary artery calcium (CAC) measurements in cardiovascular risk stratification in patients with T2DM and HTN. The study involved 423 patients enrolled in the International Nifedipine Study: Intervention as Goal for Hypertension Therapy. The patients had baseline CT scans for CAC measurement at baseline and were shown to be free of disease. Follow-up CT scans were performed at 3 and 15 years. Cardiovascular events (CVEs) occurred in 41 of 423 patients at 3 years and 111 of 268 patients at 15 years of follow-up. CVEs occurred in 15% and 52% (CAC+) and 7% and 32% (CAC-) of patients with T2DM at 3 and 15 years of follow-up, respectively. Compared to patients without T2DM and no CAC, the HRs for a CVE were 6.6 and 3.9 in T2DM patients with and without CAC, respectively.

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CAC scores add predictability to Framingham

Researchers at Erasmus University Medical Center in Rotterdam have evaluated 12 measures (N-terminal fragment of prohormone B-type natriuretic peptide levels, von Willebrand factor antigen levels, fibrinogen levels, chronic kidney disease, leukocyte count, C-reactive protein levels, homocysteine levels, uric acid levels, coronary artery calcium [CAC] scores, carotid intima–media thickness, peripheral arterial disease, and pulse wave velocity), in addition to Framingham risk scores for predicting coronary heart disease. Only the CAC was shown to add significantly to the Framingham risk score in predicting coronary heart disease.

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Most Popular Internal Medicine Articles

Last month's top read Top Articles of 2012

1 Walking Versus Running for Hypertension, Cholesterol, and Diabetes Mellitus Risk Reduction Arteriosclerosis, Thrombosis, and Vascular Biology, April 17, 2013

2 Primary Prevention of Cardiovascular Disease with a Mediterranean Diet New England Journal of Medicine, April 8, 2013 Free full text

3 Vitamin D Levels for Preventing Acute Coronary Syndrome and Mortality: Evidence of a Non-Linear Association Journal of Clinical Endocrinology and Metabolism, March 27, 2013
Exclusive Author Commentary

4 Advances in Stroke Prevention in Atrial Fibrillation: Enhanced Risk Stratification Combined With the Newer Oral Anticoagulants Clinical Cardiology, April 11, 2013 Free full text Review Article

5 Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials British Medical Journal, April 25, 2013 Evidence Based Medicine Review Article

6 The Risk of Taking Ascorbic Acid JAMA Internal Medicine, February 5, 2013

7 Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial The Lancet, April 18, 2013

8 Canagliflozin Compared With Sitagliptin for Patients With Type 2 Diabetes Who Do Not Have Adequate Glycemic Control With Metformin Plus Sulfonylurea: A 52-week randomized trial Diabetes Care, April 9, 2013

9 Enalapril And Carvedilol for Preventing Chemotherapy-Induced Left Ventricular Systolic Dysfunction in Patients with Malignant Hemopathies. The OVERCOME Trial JACC - Journal of the American College of Cardiology, April 12, 2013

10 Drug Interactions with Grapefruit Juice British Journal of Medical Practitioners, February 12, 2013 Free full text

11 Outcomes of apixaban vs. warfarin by type and duration of atrial fibrillation: results from the ARISTOTLE trial European Heart Journal, April 22, 2013

12 Pulmonary hypertension: diagnosis and management British Medical Journal, April 23, 2013 Review Article

13 Infective Endocarditis New England Journal of Medicine, April 12, 2013

14 Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels -- Results from a randomized trial European Journal of Internal Medicine , April 11, 2013

15 Vitamin D and Calcium Supplementation to Prevent Fractures in Adults: U.S. Preventive Services Task Force Recommendation Statement Annals of Internal Medicine, February 26, 2013 Clinical Guideline

16 Infective Endocarditis New England Journal of Medicine, April 24, 2013 Review Article

17 Osteoporosis treatment European Journal of Internal Medicine , April 24, 2013

18 Bone mineral density testing: Is a T score enough to determine the screening interval? Cleveland Clinic Journal of Medicine, April 3, 2013 Free full text

19 The impact of coffee on health Maturitas, February 26, 2013

20 Efficacy and safety of linagliptin in type 2 diabetes subjects at high risk for renal and cardiovascular disease: a pooled analysis of six phase III clinical trials Cardiovascular Diabetology, April 12, 2013 Free full text

Indexed Journals in Internal Medicine: New England Journal of Medicine, The Lancet, Archives of Internal Medicine more

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Internal Medicine News & Articles

Articles

Clinical Pearls in Internal Medicine

Highlights in Internal Medicine

Vitamin D deficiency is associated with increased mortality in ICU patients

Coronary artery calcium increases cardiovascular risk in patients with T2DM and HTN

CAC scores add predictability to Framingham

Most Popular Internal Medicine Articles

Other Topics in Internal Medicine