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Ranked, sorted, and summarized by MDLinx editors from the latest literature
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1 Genetic basis for clinical response to CTLA–4 blockade in melanoma New England Journal of Medicine, November 24, 2014    Evidence Based Medicine    Clinical Article

2 Glycemic control and excess mortality in type 1 diabetes New England Journal of Medicine, November 24, 2014    Evidence Based Medicine    Clinical Article

3 Surgical treatment of moderate ischemic mitral regurgitation New England Journal of Medicine, November 24, 2014    Evidence Based Medicine    Clinical Article

4 HDL cholesterol efflux capacity and incident cardiovascular events New England Journal of Medicine, November 24, 2014    Evidence Based Medicine    Clinical Article

5 Atenolol versus losartan in children and young adults with Marfan's syndrome New England Journal of Medicine, November 24, 2014    Evidence Based Medicine    Clinical Article

6 Association of impaired fasting glucose, diabetes and their management with the presentation and outcome of peripheral artery disease: a cohort study Full Text Cardiovascular Diabetology, November 24, 2014    Clinical Article

7 Comparison of scoring methods for the Brief Insomnia Questionnaire in a general population sample Journal of Psychosomatic Research, November 24, 2014    Evidence Based Medicine

8 Development and validation of an infertility stigma scale for Chinese women Journal of Psychosomatic Research, November 24, 2014    Evidence Based Medicine
Exclusive Author Commentary

9 The importance of fatigue cognitions in chronic hepatitis C infection Journal of Psychosomatic Research, November 24, 2014    Evidence Based Medicine

10 Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: A retrospective cohort study The Lancet Oncology, November 24, 2014    Clinical Article

11 Mycoplasma genitalium is associated with increased genital HIV-1 RNA in Zimbabwean women The Journal of Infectious Diseases, November 24, 2014    Clinical Article

12 Minority resistant HIV-1 variants and the response to first-line NNRTI therapy Journal of Clinical Virology, November 24, 2014    Clinical Article

13 Diagnostic accuracy of self-reported arthritis in the general adult population is acceptable Journal of Clinical Epidemiology, November 24, 2014    Review Article

14 The influence of comorbid chronic physical conditions on depression recognition in primary care: a systematic review Journal of Psychosomatic Research, November 24, 2014    Evidence Based Medicine

15 Effectiveness and cost of quick diagnostic tests to determine tetanus immunity in patients with a wound in French emergency departments Full Text BMC Infectious Diseases, November 24, 2014    Clinical Article

16 Efficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes mellitus patients with moderate to severe renal impairment: a systematic review and meta-analysis PLOS ONE, November 24, 2014    Evidence Based Medicine    Review Article

17 Mechanisms underlying exaggerated metaboreflex activation in prehypertensive men Medicine and Science in Sports and Exercise, November 24, 2014    Evidence Based Medicine

18 The effects of an injected placebo on endurance running performance Medicine and Science in Sports and Exercise, November 24, 2014    Evidence Based Medicine

19 The effect of ischemic preconditioning on repeated sprint cycling performance Medicine and Science in Sports and Exercise, November 24, 2014    Evidence Based Medicine

20 Home-based exercise improves fitness and exercise attitude and intention in GDM women Medicine and Science in Sports and Exercise, November 24, 2014    Evidence Based Medicine

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Highlights in Internal Medicine

Sleep duration linked to lung cancer risk

As reported in BMC Public Health, men (age range, 42-60 years) who slept < 7 h/night or > 8 h/night are at increased risk for lung cancer. Specifically, amongst current smokers, the HR for lung cancer in men who slept < 6.5 h/night or > 8 h/night was 2.23 and 2.09, respectively. It is thought that melatonin excretion and/or low-grade inflammation account for this observation.

Muscle strength in adolescence decreases CVD risk

As reported in BMC Medicine, adolescents (n=38588) with the highest tertile of muscle strength had a decreased risk of CVD (HR=0.88) compared to adolescents with the lowest tertile of muscle strength after 42 y of follow-up. Of note, low muscle strength in adolescence by itself had no effect on CVD risk in middle age (HR=0.99). In contrast, high muscle strength in adolescence significantly decreased the risk of CVD in middle age (HR=1.31).

Relationship benefit in women with IHD

As reported in Clinical Infectious Diseases, HIV-infected patients are at increased risk for non-Hodgkin‘s lymphoma (NHL). Of 6036 patients with 21607 person-years of follow-up, there were 37 incident cases of NHL. Compared to patients with ≤ 50 copies/mL, patients with 51-500 and > 500 copies/mL had HRs of 1.66 and 2.39 for NHL, respectively.


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