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Ranked, sorted, and summarized by MDLinx editors from the latest literature
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1 Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial The Lancet, August 21, 2014    Evidence Based Medicine    Clinical Article

2 Effect of a quadrivalent meningococcal ACWY glycoconjugate or a serogroup B meningococcal vaccine on meningococcal carriage: an observer-blind, phase 3 randomised clinical trial The Lancet, August 21, 2014    Evidence Based Medicine    Clinical Article

3 Late diagnosis of hepatitis C virus infection in the Chronic Hepatitis Cohort Study (CHeCS): Missed opportunities for intervention Hepatology, August 21, 2014    Clinical Article

4 Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults The Lancet, August 21, 2014    Evidence Based Medicine

5 The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial The Lancet, August 21, 2014    Evidence Based Medicine    Clinical Article

6 Increased intake of vegetables, but not fruit, reduces risk for hepatocellular carcinoma: A meta-analysis Gastroenterology, August 21, 2014    Clinical Article

7 Converging goals of treatment for inflammatory bowel disease, from clinical trials and practice Gastroenterology, August 21, 2014    Clinical Article

8 Patient-reported outcomes in randomised controlled trials of prostate cancer: Methodological quality and impact on clinical decision making Full Text European Urology, August 21, 2014    Clinical Article

9 Polymorphisms of HLA-DP are associated with response to peginterferon in Caucasian patients with chronic hepatitis B Alimentary Pharmacology and Therapeutics, August 21, 2014    Clinical Article

10 Using clinicians search query data to monitor influenza epidemics Clinical Infectious Diseases, August 21, 2014    Clinical Article

11 Acute muscular sarcocystosis: An international investigation among ill travelers returning from Tioman island, Malaysia, 2011 and 2012 Clinical Infectious Diseases, August 21, 2014    Clinical Article

12 Safety of continuous periprocedural rivaroxaban for patients undergoing left atrial catheter ablation procedures Circulation: Arrhythmia and Electrophysiology, August 21, 2014    Clinical Article

13 Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase Circulation: Arrhythmia and Electrophysiology, August 21, 2014    Clinical Article

14 Early repolarization increases the occurrence of sustained ventricular tachyarrhythmias and sudden death in the chronic phase of an acute myocardial infarction Circulation: Arrhythmia and Electrophysiology, August 21, 2014    Clinical Article

15 Physical activity, obesity, weight change, and risk of atrial fibrillation Circulation: Arrhythmia and Electrophysiology, August 21, 2014    Clinical Article

16 Ubiquitous myocardial extensions into the pulmonary artery demonstrated by integrated intracardiac echocardiography and electroanatomic mapping Circulation: Arrhythmia and Electrophysiology, August 21, 2014    Clinical Article

17 Noninducibility in postinfarction ventricular tachycardia as an end point for ventricular tachycardia ablation and its effects on outcomes Circulation: Arrhythmia and Electrophysiology, August 21, 2014    Evidence Based Medicine    Review Article

18 Effects of pitavastatin versus atorvastatin on the peripheral endothelial progenitor cells and vascular endothelial growth factor in high-risk patients: a pilot prospective, double-blind, randomized study Full Text Cardiovascular Diabetology, August 21, 2014    Clinical Article

19 PR interval identifies clinical response in patients with non–left bundle branch block Circulation: Arrhythmia and Electrophysiology, August 21, 2014    Clinical Article

20 Resumption of chest compressions after successful defibrillation and risk for recurrence of ventricular fibrillation in out-of-hospital cardiac arrest Circulation: Arrhythmia and Electrophysiology, August 21, 2014    Clinical Article

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Highlights in Internal Medicine

Relationship benefit in women with IHD

As reported in Clinical Infectious Diseases, HIV-infected patients are at increased risk for non-Hodgkin‘s lymphoma (NHL). Of 6036 patients with 21607 person-years of follow-up, there were 37 incident cases of NHL. Compared to patients with ≤ 50 copies/mL, patients with 51-500 and > 500 copies/mL had HRs of 1.66 and 2.39 for NHL, respectively.

Soluble TNF receptor II increased in MS patients

As reported in the Journal of Neuroimmunology, soluble tumor necrosis factor receptor II levels are increased in patients with untreated multiple sclerosis (n-161) compared to healthy controls (n=46), and the levels increased over a 2-year follow-up, but were not associated with the severity of disability.

Muscle strength in adolescence decreases CVD risk

As reported in BMC Medicine, adolescents (n=38588) with the highest tertile of muscle strength had a decreased risk of CVD (HR=0.88) compared to adolescents with the lowest tertile of muscle strength after 42 y of follow-up. Of note, low muscle strength in adolescence by itself had no effect on CVD risk in middle age (HR=0.99). In contrast, high muscle strength in adolescence significantly decreased the risk of CVD in middle age (HR=1.31).


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