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Ranked, sorted, and summarized by MDLinx editors from the latest literature
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1 A bioresorbable everolimus-eluting scaffold versus a metallic everolimus-eluting stent for ischaemic heart disease caused by de-novo native coronary artery lesions (ABSORB II): an interim 1-year analysis of clinical and procedural secondary outcomes from a randomised controlled trial The Lancet, September 18, 2014    Evidence Based Medicine    Clinical Article

2 Use of thoracic radiotherapy for extensive stage small-cell lung cancer: a phase 3 randomised controlled trial The Lancet, September 18, 2014    Evidence Based Medicine    Clinical Article

3 Evaluation and treatment of older patients with hypercholesterolemia: a clinical review JAMA, September 18, 2014    Evidence Based Medicine    Clinical Article

4 Combination long-acting {beta}-agonists and inhaled corticosteroids compared with long-acting {beta}-agonists alone in older adults with chronic obstructive pulmonary disease JAMA, September 18, 2014    Evidence Based Medicine    Clinical Article

5 Clinical and safety outcomes associated with treatment of acute venous thromboembolism: a systematic review and meta-analysis JAMA, September 18, 2014    Evidence Based Medicine    Clinical Article

6 Perimortem trauma in King Richard III: a skeletal analysis The Lancet, September 18, 2014    Evidence Based Medicine    Clinical Article

7 Apgar score and the risk of cause-specific infant mortality: a population-based cohort study The Lancet, September 18, 2014    Evidence Based Medicine    Clinical Article

8 Treating prescription opioid dependence JAMA, September 18, 2014    Evidence Based Medicine    Clinical Article

9 Serum 25-hydroxyvitamin D, mortality, and incident cardiovascular disease, respiratory disease, cancers, and fractures: a 13-y prospective population study American Journal of Clinical Nutrition, September 18, 2014    Clinical Article

10 Phase II study of the safety and antitumor activity of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma Journal of Clinical Oncology, September 18, 2014    Clinical Article

11 Fish-oil supplementation alters numbers of circulating endothelial progenitor cells and microparticles independent of eNOS genotype American Journal of Clinical Nutrition, September 18, 2014    Clinical Article

12 Longer examination time improves detection of gastric cancer during diagnostic upper gastrointestinal endoscopy Clinical Gastroenterology and Hepatology , September 18, 2014    Clinical Article

13 The influence of prior abiraterone treatment on the clinical activity of docetaxel in men with metastatic castration-resistant prostate cancer Full Text European Urology, September 18, 2014    Clinical Article

14 A novel combined biomarker including plasma carotenoids, vitamin C, and ferric reducing antioxidant power is more strongly associated with fruit and vegetable intake than the individual components The Journal of Nutrition, September 18, 2014    Clinical Article

15 Criterion validation of two submaximal aerobic fitness tests, the self-monitoring Fox-walk test and the Astrand cycle test in people with rheumatoid arthritis Full Text BMC Musculoskeletal Disorders, September 18, 2014    Evidence Based Medicine    Clinical Article

16 The role of focal therapy in the management of localised prostate cancer: A systematic review Full Text European Urology, September 18, 2014    Evidence Based Medicine    Review Article

17 The loss of 5-methyltetrahydrofolate in human serum under suboptimal preanalytical conditions can only partially be recovered by an oxidation product The Journal of Nutrition, September 18, 2014    Clinical Article

18 PBMC of HIV-infected patients contain CD8 T cells that form conjugates with and kill HIV- infected autologous CD4 T cells Immunology, September 18, 2014    Clinical Article

19 Altered cellular and humoral immunity to varicella-zoster virus in patients with autoimmune diseases Arthritis & Rheumatism, September 18, 2014    Clinical Article

20 Ecoimmunology for psychoneuroimmunologists: considering context in neuroendocrine–immune–behavior interactions Brain, Behavior, and Immunity, September 18, 2014    Clinical Article

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Clinical Pearls in Internal Medicine

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Highlights in Internal Medicine

Relationship benefit in women with IHD

As reported in Clinical Infectious Diseases, HIV-infected patients are at increased risk for non-Hodgkin‘s lymphoma (NHL). Of 6036 patients with 21607 person-years of follow-up, there were 37 incident cases of NHL. Compared to patients with ≤ 50 copies/mL, patients with 51-500 and > 500 copies/mL had HRs of 1.66 and 2.39 for NHL, respectively.

Sleep duration linked to lung cancer risk

As reported in BMC Public Health, men (age range, 42-60 years) who slept < 7 h/night or > 8 h/night are at increased risk for lung cancer. Specifically, amongst current smokers, the HR for lung cancer in men who slept < 6.5 h/night or > 8 h/night was 2.23 and 2.09, respectively. It is thought that melatonin excretion and/or low-grade inflammation account for this observation.

Mean platelet volume predicts silent cerebral infarction

As reported in the Internal Medicine Journal, the mean platelet volume is increased in patients with a silent cerebral infarction than in those without (10.4 vs. 9.2 fL). The OR for silent cerebral infarction was 7.822 in patients in the highest mean platelet volume quartile compared to the lowest quartile.


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