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Ranked, sorted, and summarized by MDLinx editors from the latest literature
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1 Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial The Lancet, December 19, 2014    Evidence Based Medicine    Clinical Article

2 Low-dose aspirin for primary prevention of cardiovascular events in japanese patients 60 years or older with atherosclerotic risk factors: a randomized clinical trial JAMA, December 19, 2014    Evidence Based Medicine    Clinical Article

3 Efficacy and safety of 8 weeks versus 12 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin in patients with hepatitis C virus genotype 1 mono-infection and HIV/hepatitis C virus co-infection (C-WORTHY): a randomised, open-label phase 2 trial The Lancet, December 19, 2014    Evidence Based Medicine    Clinical Article

4 Effect of neonatal vitamin A supplementation on mortality in infants in Tanzania (Neovita): a randomised, double-blind, placebo-controlled trial The Lancet, December 19, 2014    Evidence Based Medicine    Clinical Article

5 The validity of self-reported body mass index in a population-based osteoarthritis study Full Text BMC Musculoskeletal Disorders, December 19, 2014    Evidence Based Medicine    Clinical Article

6 Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial The Lancet, December 19, 2014    Evidence Based Medicine    Clinical Article

7 Effects of Spirulina platensis supplementation on lipid profile in HIV-infected antiretroviral naive patients in Yaounde - Cameroon: a randomized trial study Full Text Lipids in Health and Disease, December 19, 2014    Evidence Based Medicine    Clinical Article

8 A multifaceted intervention: No increase in general practitioners' competence to diagnose skin cancer (minSKIN) - randomized controlled trial Journal of the European Academy of Dermatology and Venereology, December 19, 2014    Clinical Article

9 CT enteroclysis/enterography findings in drug-induced small-bowel damage The British Journal of Radiology, December 19, 2014    Clinical Article

10 Is there a link between liraglutide and pancreatitis? A post hoc review of pooled and patient-level data from completed liraglutide type 2 diabetes clinical trials Diabetes Care, December 19, 2014    Review Article

11 Impact of replacing smear microscopy with Xpert MTB/RIF for diagnosing tuberculosis in Brazil: A stepped-wedge cluster-randomized trial Full Text PLoS Medicine, December 19, 2014    Evidence Based Medicine    Clinical Article

12 Epidemiological and viral genomic sequence analysis of the 2014 Ebola outbreak reveals clustered transmission Clinical Infectious Diseases, December 19, 2014    Clinical Article

13 Incident BV in women who have sex with women is associated with behaviours that suggest sexual transmission of BV Clinical Infectious Diseases, December 19, 2014    Clinical Article

14 Protracted fecal shedding of HEV during ribavirin therapy predicts treatment relapse Clinical Infectious Diseases, December 19, 2014    Clinical Article

15 Reduced retention of Pittsburgh compound B in white matter lesions European Journal of Nuclear Medicine & Molecular Imaging, December 19, 2014    Clinical Article

16 Performance of pro-adrenomedullin for identifying adverse outcomes in heterogeneous group of patients with community-acquired pneumonia Journal of Infection, December 19, 2014    Clinical Article

17 Charged particle therapy versus photon therapy for patients with hepatocellular carcinoma: A systematic review and meta-analysis Radiotherapy & Oncology, December 19, 2014    Evidence Based Medicine    Review Article

18 B-Mode and acoustic radiation force impulse (ARFI) imaging of prostate zonal anatomy: Comparison with 3T T2-weighted MR imaging Ultrasonic Imaging, December 19, 2014    Clinical Article

19 Randomized phase II trial of gemcitabine plus TH-302 versus gemcitabine in patients with advanced pancreatic cancer Journal of Clinical Oncology, December 19, 2014    Clinical Article

20 The effect of metformin on glucose homeostasis during moderate exercise Diabetes Care, December 19, 2014    Clinical Article

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Highlights in Internal Medicine

Mean platelet volume predicts silent cerebral infarction

As reported in the Internal Medicine Journal, the mean platelet volume is increased in patients with a silent cerebral infarction than in those without (10.4 vs. 9.2 fL). The OR for silent cerebral infarction was 7.822 in patients in the highest mean platelet volume quartile compared to the lowest quartile.

Sleep duration linked to lung cancer risk

As reported in BMC Public Health, men (age range, 42-60 years) who slept < 7 h/night or > 8 h/night are at increased risk for lung cancer. Specifically, amongst current smokers, the HR for lung cancer in men who slept < 6.5 h/night or > 8 h/night was 2.23 and 2.09, respectively. It is thought that melatonin excretion and/or low-grade inflammation account for this observation.

Relationship benefit in women with IHD

As reported in Clinical Infectious Diseases, HIV-infected patients are at increased risk for non-Hodgkin‘s lymphoma (NHL). Of 6036 patients with 21607 person-years of follow-up, there were 37 incident cases of NHL. Compared to patients with ≤ 50 copies/mL, patients with 51-500 and > 500 copies/mL had HRs of 1.66 and 2.39 for NHL, respectively.


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