Internal Medicine News Articles

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Ranked, sorted, and summarized by MDLinx editors from the latest literature
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1 Ivabradine in stable coronary artery disease without clinical heart failure New England Journal of Medicine, September 2, 2014    Evidence Based Medicine    Clinical Article

2 Integrated collaborative care for comorbid major depression in patients with cancer (SMaRT Oncology-2): a multicentre randomised controlled effectiveness trial The Lancet, September 2, 2014    Evidence Based Medicine    Clinical Article

3 Angiotensin-neprilysin inhibition versus enalapril in heart failure New England Journal of Medicine, September 2, 2014    Evidence Based Medicine    Clinical Article

4 Ultrathin strut biodegradable polymer sirolimus-eluting stent versus durable polymer everolimus-eluting stent for percutaneous coronary revascularisation (BIOSCIENCE): a randomised, single-blind, non-inferiority trial The Lancet, September 2, 2014    Evidence Based Medicine    Clinical Article

5 Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region: an open-label, randomised, controlled, non-inferiority trial The Lancet, September 2, 2014    Evidence Based Medicine    Clinical Article

6 Preventing functional loss during immobilization after osteoporotic wrist fractures in elderly patients: a randomized clinical trial Full Text BMC Musculoskeletal Disorders, September 2, 2014    Evidence Based Medicine    Clinical Article

7 Fertility in women with rheumatoid arthritis: Influence of disease activity and medication Annals of Rheumatic Diseases, September 2, 2014    Clinical Article

8 Osteopathic manipulative treatment for nonspecific low back pain: a systematic review and meta-analysis Full Text BMC Musculoskeletal Disorders, September 2, 2014    Evidence Based Medicine    Clinical Article

9 A negative confirmatory biopsy among men on active surveillance for prostate cancer does not protect them from histologic grade progression Full Text European Urology, September 2, 2014    Clinical Article

10 A different method of evaluation of the ERSPC trial confirms that prostate-specific antigen testing has a significant impact on prostate cancer mortality Full Text European Urology, September 2, 2014    Clinical Article

11 Candidate lesion-based criteria for defining a positive sacroiliac joint MRI in two cohorts of patients with axial spondyloarthritis Annals of Rheumatic Diseases, September 2, 2014    Clinical Article

12 Impact of the leucocyte immunoglobulin-like receptor A3 (LILRA3) on susceptibility and subphenotypes of systemic lupus erythematosus and Sjogren's syndrome Annals of Rheumatic Diseases, September 2, 2014    Clinical Article

13 Intensive combination treatment regimens, including prednisolone, are effective in treating patients with early rheumatoid arthritis regardless of additional etanercept: 1-year results of the COBRA-light open-label, randomised, non-inferiority trial Annals of Rheumatic Diseases, September 2, 2014    Clinical Article

14 Hypertonic dextrose versus corticosteroid local injection for the treatment of osteoarthritis in the first carpometacarpal joint: A double-blind randomized clinical trial Journal of Orthopaedic Science, September 2, 2014    Evidence Based Medicine    Clinical Article

15 Increased burden of inflammation over time is associated with the extent of atherosclerotic plaques in patients with psoriatic arthritis Annals of Rheumatic Diseases, September 2, 2014    Clinical Article

16 Is the adjuvanted influenza vaccine more effective than the trivalent inactivated vaccine in the elderly population? Results of a case–control study Vaccine , September 2, 2014    Clinical Article

17 Seroprevalence of IgG antibodies to pertussis toxin in children and adolescents in Estonia Vaccine , September 2, 2014    Clinical Article

18 Influenza vaccine effectiveness against medically-attended influenza illness during the 2012-2013 season in Beijing, China Vaccine , September 2, 2014    Clinical Article

19 Facial Angiofibroma Severity Index (FASI): Reliability assessment of a new tool developed to measure severity and responsiveness to therapy in tuberous sclerosis-associated facial angiofibroma Clinical and Experimental Dermatology, September 2, 2014    Clinical Article

20 Integrated collaborative care for major depression comorbid with a poor prognosis cancer (SMaRT Oncology-3): A multicentre randomised controlled trial in patients with lung cancer The Lancet Oncology, September 2, 2014    Clinical Article

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Highlights in Internal Medicine

Relationship benefit in women with IHD

As reported in Clinical Infectious Diseases, HIV-infected patients are at increased risk for non-Hodgkin‘s lymphoma (NHL). Of 6036 patients with 21607 person-years of follow-up, there were 37 incident cases of NHL. Compared to patients with ≤ 50 copies/mL, patients with 51-500 and > 500 copies/mL had HRs of 1.66 and 2.39 for NHL, respectively.

Mean platelet volume predicts silent cerebral infarction

As reported in the Internal Medicine Journal, the mean platelet volume is increased in patients with a silent cerebral infarction than in those without (10.4 vs. 9.2 fL). The OR for silent cerebral infarction was 7.822 in patients in the highest mean platelet volume quartile compared to the lowest quartile.

Muscle strength in adolescence decreases CVD risk

As reported in BMC Medicine, adolescents (n=38588) with the highest tertile of muscle strength had a decreased risk of CVD (HR=0.88) compared to adolescents with the lowest tertile of muscle strength after 42 y of follow-up. Of note, low muscle strength in adolescence by itself had no effect on CVD risk in middle age (HR=0.99). In contrast, high muscle strength in adolescence significantly decreased the risk of CVD in middle age (HR=1.31).


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