1A 9-valent HPV vaccine against infection and intraepithelial neoplasia in womenNew England Journal of Medicine  Clinical Article  Evidence Based Medicine
2Community-acquired pneumonia requiring hospitalization among U.S. childrenNew England Journal of Medicine  Clinical Article  Evidence Based Medicine
3Association of NSAID use with risk of bleeding and cardiovascular events in patients receiving antithrombotic therapy after myocardial infarctionJAMA  Clinical Article  Evidence Based Medicine
4Glomerular filtration rate and albuminuria for detection and staging of acute and chronic kidney disease in adults: a systematic reviewJAMA  Clinical Article  Review Article
5Quality of life, anxiety, depression and obsessive-compulsive tendencies in patients with chronic hand eczemaContact Dermatitis  Clinical Article
6Democracy-based consensus in medicineJournal of Cardiothoracic and Vascular Anesthesia  Review Article
7Hospital volume and failure to rescue after head and neck cancer surgeryOtolaryngology - Head and Neck Surgery  Clinical Article
8Omega-3 fatty acids and vitamin D may control brain serotonin, affecting behavior and psychiatric disordersUCSF Benioff Children's Hospital Oakland News
9Safety and activity of alisertib, an investigational aurora kinase A inhibitor, in patients with breast cancer, small-cell lung cancer, non-small-cell lung cancer, head and neck squamous-cell carcinoma, and gastro-oesophageal adenocarcinoma: A five-arm phase 2 studyThe Lancet Oncology  Clinical Article
10Patients with mantle cell lymphoma failing ibrutinib are unlikely to respond to salvage chemotherapy and have poor outcomesAnnals of Oncology  Clinical Article
1NIH-funded researchers identify genetic region associated with peanut allergyNational Institute of Allergy and Infectious Disease - News
2Shake it off? Not so easy for people with depression, new brain research suggestsUniversity of Michigan Health System
3Cystic fibrosis discovery may lead to new treatment strategy to help patients breathe easierUCSF News
4Prescription opioid analgesic use among adults: United States, 1999–2012U.S. National Center for Health Statistics News
5The numbers are in: 1.8m Australian smokers likely to die from their habitUniversity of Melbourne News
6A virtual reality check for medical studentsOhio State University News
7Million man study examines long-term effects of blocking inflammationUniversity of Cambridge News
8Sleeping over eight hours a day associated with greater risk of strokeUniversity of Cambridge News
9Widely used food additive promotes colitis, obesity and metabolic syndrome, research showsGeorgia State University News
10Could an HIV drug beat strep throat, flesh-eating bacteria?American Chemical Society News

Show Me:

Mean platelet volume predicts silent cerebral infarction

As reported in the Internal Medicine Journal, the mean platelet volume is increased in patients with a silent cerebral infarction than in those without (10.4 vs. 9.2 fL). The OR for silent cerebral infarction was 7.822 in patients in the highest mean platelet volume quartile compared to the lowest quartile.

Relationship benefit in women with IHD

As reported in Clinical Infectious Diseases, HIV-infected patients are at increased risk for non-Hodgkin‘s lymphoma (NHL). Of 6036 patients with 21607 person-years of follow-up, there were 37 incident cases of NHL. Compared to patients with ≤ 50 copies/mL, patients with 51-500 and > 500 copies/mL had HRs of 1.66 and 2.39 for NHL, respectively.

Soluble TNF receptor II increased in MS patients

As reported in the Journal of Neuroimmunology, soluble tumor necrosis factor receptor II levels are increased in patients with untreated multiple sclerosis (n-161) compared to healthy controls (n=46), and the levels increased over a 2-year follow-up, but were not associated with the severity of disability.

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Clinical Pearls

Clinical Pearl from Smartest DocHER2-status is not an independent prognostic factor in metastatic gastric cancer or gastroesophageal junction adenocarcinoma

Clinical Pearl from Smartest DocTroponin measurements at point-of-care require further development.

Clinical Pearl from Smartest DocAntipsychotic use in patients with dementia is associated with weight gain.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List