Internal Medicine News Articles

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Ranked, sorted, and summarized by MDLinx editors from the latest literature
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1 Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial The Lancet, July 25, 2014    Evidence Based Medicine    Clinical Article

2 Adverse outcomes after total and unicompartmental knee replacement in 101 330 matched patients: a study of data from the National Joint Registry for England and Wales The Lancet, July 25, 2014    Evidence Based Medicine    Clinical Article

3 Effect of a single inactivated poliovirus vaccine dose on intestinal immunity against poliovirus in children previously given oral vaccine: an open-label, randomised controlled trial The Lancet, July 25, 2014    Evidence Based Medicine    Clinical Article

4 Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial The Lancet, July 25, 2014    Evidence Based Medicine    Clinical Article

5 Inhibition of the mTORC pathway in the antiphospholipid syndrome New England Journal of Medicine, July 25, 2014    Evidence Based Medicine    Clinical Article

6 Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial The Lancet, July 25, 2014    Evidence Based Medicine    Clinical Article

7 45-day mortality after 467 779 knee replacements for osteoarthritis from the National Joint Registry for England and Wales: an observational study The Lancet, July 25, 2014    Evidence Based Medicine    Clinical Article

8 Survival for haematological malignancies in Europe between 1997 and 2008 by region and age: results of EUROCARE-5, a population-based study The Lancet Oncology, July 25, 2014    Clinical Article

9 UK and European Union public and charitable funding from 2008 to 2013 for bacteriology and antibiotic research in the UK: An observational study The Lancet Infectious Diseases, July 25, 2014    Clinical Article

10 Comparison of the treatment implications of American Society of Hypertension and International Society of Hypertension 2013 and Eighth Joint National Committee Guidelines: An analysis of national health and nutrition examination survey Hypertension, July 25, 2014    Clinical Article

11 Safety and efficacy of aerobic training in patients with cancer who have heart failure: an analysis of the HF-ACTION randomized trial Journal of Clinical Oncology, July 25, 2014    Clinical Article

12 Plasma vitamin D concentration influences survival outcome after a diagnosis of colorectal cancer Journal of Clinical Oncology, July 25, 2014    Clinical Article

13 Decreased HIV type 1 transcription in CCR5-{delta}32 heterozygotes during suppressive antiretroviral therapy The Journal of Infectious Diseases, July 25, 2014    Clinical Article

14 Efficacy of methylprednisolone on pain, fatigue, and appetite loss in patients with advanced cancer using opioids: a randomized, placebo-controlled, double-blind trial Journal of Clinical Oncology, July 25, 2014    Clinical Article

15 Telomere shortening over 6 years is associated with increased subclinical carotid vascular damage and worse cardiovascular prognosis in the general population Journal of Internal Medicine, July 25, 2014    Evidence Based Medicine

16 Relation between blood pressure and mortality risk in an older population: role of chronological and biological age Journal of Internal Medicine, July 25, 2014    Evidence Based Medicine

17 Vitamin D and cognition in older adults: updated international recommendations Journal of Internal Medicine, July 25, 2014    Evidence Based Medicine

18 Online social networking services in the management of patients with diabetes mellitus: Systematic review and meta-analysis of randomised controlled trials Diabetes Research and Clinical Practice, July 25, 2014    Evidence Based Medicine    Review Article    Clinical Article

19 One-week intervention period led to improvements in glycemic control and reduction in DNA damage levels in patients with type 2 diabetes mellitus Diabetes Research and Clinical Practice, July 25, 2014    Clinical Article

20 α-Lipoic acid reduces fatty acid esterification and lipogenesis in adipocytes from overweight/obese subjects Obesity, July 25, 2014    Clinical Article

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Clinical Pearls in Internal Medicine

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Highlights in Internal Medicine

Sleep duration linked to lung cancer risk

As reported in BMC Public Health, men (age range, 42-60 years) who slept < 7 h/night or > 8 h/night are at increased risk for lung cancer. Specifically, amongst current smokers, the HR for lung cancer in men who slept < 6.5 h/night or > 8 h/night was 2.23 and 2.09, respectively. It is thought that melatonin excretion and/or low-grade inflammation account for this observation.

Soluble TNF receptor II increased in MS patients

As reported in the Journal of Neuroimmunology, soluble tumor necrosis factor receptor II levels are increased in patients with untreated multiple sclerosis (n-161) compared to healthy controls (n=46), and the levels increased over a 2-year follow-up, but were not associated with the severity of disability.

Muscle strength in adolescence decreases CVD risk

As reported in BMC Medicine, adolescents (n=38588) with the highest tertile of muscle strength had a decreased risk of CVD (HR=0.88) compared to adolescents with the lowest tertile of muscle strength after 42 y of follow-up. Of note, low muscle strength in adolescence by itself had no effect on CVD risk in middle age (HR=0.99). In contrast, high muscle strength in adolescence significantly decreased the risk of CVD in middle age (HR=1.31).


Other Topics in Internal Medicine

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