The Latest Clinical Articles in Internal Medicine & General Medicine

1Bivalirudin vs heparin with or without tirofiban during primary percutaneous coronary intervention in acute myocardial infarction: the bright randomized clinical trialJAMA, March 31, 2015  Clinical Article  Evidence Based Medicine
2Virologic response following combined ledipasvir and sofosbuvir administration in patients with HCV genotype 1 and HIV co-infectionJAMA, March 31, 2015  Clinical Article  Evidence Based Medicine
3Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variantsJAMA, March 31, 2015  Clinical Article  Evidence Based Medicine
4Ombitasvir, paritaprevir co-dosed with ritonavir, dasabuvir, and ribavirin for hepatitis C in patients co-infected with HIV-1 a randomized trialJAMA, March 31, 2015  Clinical Article  Evidence Based Medicine
5Diagnostic concordance among pathologists interpreting breast biopsy specimensJAMA, March 31, 2015  Clinical Article  Evidence Based Medicine
6Nucleotide-binding oligomerization domain 2 receptor is expressed in platelets and enhances platelet activation and thrombosisCirculation, March 31, 2015  Clinical Article
7Magnetic resonance imaging in active surveillance of prostate cancer: A systematic reviewEuropean Urology, March 31, 2015  Full Text  Evidence Based Medicine  Review Article
8Outcomes with abiraterone acetate in metastatic castration-resistant prostate cancer patients who have poor performance statusEuropean Urology, March 31, 2015  Full Text  Clinical Article
9ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1Circulation, March 31, 2015  Clinical Article
10Angiographic characteristics of intermediate stenosis of the left anterior descending artery for determination of lesion significance as identified by fraction flow reserve measurementsThe American Journal of Cardiology, March 31, 2015  Clinical Article
1NCCN publishes new guidelines for smoking cessation, effort led by Ohio State oncologistThe OSUCCC–James, March 31, 2015
2How to get smarter on pills for seniorsThomas Jefferson University News, March 31, 2015
3Genetic background determines whether aspirin/NSAIDS will reduce colorectal cancer riskMassachusetts General Hospital, March 31, 2015
4Who will develop memory problems? New tool may help predictAmerican Academy of Neurology News, March 31, 2015
5Drinking raw milk dramatically increases risk for foodborne illness, analysis findsJohns Hopkins Bloomberg School of Public Health, March 31, 2015
6State-of-the-art review explores management of anticoagulation in Afib patientsAmerican College of Cardiology News, March 31, 2015
7FDA warns against combination of hepatitis C treatment and antiarrhythmic drugAmerican College of Cardiology News, March 31, 2015
8Hormones with statins may help women's hearts after menopauseThe North American Menopause Society News, March 31, 2015
9New study links urinary troubles at menopause with sleep, body fat, reaction timeThe North American Menopause Society News, March 31, 2015
10Brain processes ongoing pain more emotionallyTechnische Universität München, March 31, 2015

Show Me:

Sleep duration linked to lung cancer risk

As reported in BMC Public Health, men (age range, 42-60 years) who slept < 7 h/night or > 8 h/night are at increased risk for lung cancer. Specifically, amongst current smokers, the HR for lung cancer in men who slept < 6.5 h/night or > 8 h/night was 2.23 and 2.09, respectively. It is thought that melatonin excretion and/or low-grade inflammation account for this observation.

Mean platelet volume predicts silent cerebral infarction

As reported in the Internal Medicine Journal, the mean platelet volume is increased in patients with a silent cerebral infarction than in those without (10.4 vs. 9.2 fL). The OR for silent cerebral infarction was 7.822 in patients in the highest mean platelet volume quartile compared to the lowest quartile.

Relationship benefit in women with IHD

As reported in Clinical Infectious Diseases, HIV-infected patients are at increased risk for non-Hodgkin‘s lymphoma (NHL). Of 6036 patients with 21607 person-years of follow-up, there were 37 incident cases of NHL. Compared to patients with ≤ 50 copies/mL, patients with 51-500 and > 500 copies/mL had HRs of 1.66 and 2.39 for NHL, respectively.

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Clinical Pearl from Smartest DocHepatitis A is the only hepatitis virus NOT associated with chronic hepatitis infection (>6 months duration)

Clinical Pearl from Smartest DocSix-month survival of severe alcohol hepatitis is not improved by combining prednisolone and pentoxifylline.

Clinical Pearl from Smartest DocHypertriglyceridemia increases the risk for stone recurrence in patients with urolithiasis.

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