Association analysis of BMD-associated SNPs with knee osteoarthritis

Journal of Bone and Mineral Research, 12/16/2013

Osteoarthritis (OA) risk is widely recognized to be heritable but few loci have been identified. Observational studies have identified higher systemic bone mineral density (BMD) to be associated with an increased risk of radiographic knee osteoarthritis. This meta–analysis demonstrates that several GWAS–identified BMD SNPs are nominally associated with prevalent radiographic knee OA and further supports the hypothesis that BMD, or its determinants, may be a risk factor contributing to OA development.

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