Interleukin-10 and Interleukin-10Receptor Defects in Inflammatory Bowel Disease
Current Allergy and Asthma Reports, 08/20/2012
Shah N et al. – Inflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by abdominal pain, bloody diarrhoea, and malabsorption leading to weight loss. It is considered the result of inadequate control of an excessive reaction of the immune system to the resident flora of the gut. Like other primary immunodeficiencies, IL–10 and IL–10 receptor (IL10R) deficiency present with IBD and demonstrate the sensitivity of the intestine to any changes of the immune system.