Marrow stromal cells induce B7-H1 expression on myeloma cells, generating aggressive characteristics in multiple myeloma
Leukemia, 08/20/2012
Tamura H et al. – The data indicate that the bone marrow (BM) microenvironment upregulates B7–H1 expression on myeloma cells, which links to the two biological actions of inducing T–cell downregulation and enhancing aggressive myeloma–cell characteristics. Modulating the B7–H1 pathway may be worthwhile in myeloma.
