Reactive Oxygen Species and the MEK/ERK Pathway are Involved in the Toxicity of Clostridium perfringens α-toxin, a Prototype Bacterial Phospholipase C
The Journal of Infectious Diseases, 08/21/2012
Monturiol–Gross L et al. – The data show that antioxidants and MEK1 inhibitors reduce the cytotoxic and myotoxic effects of α–toxin and demonstrate that edaravone, a clinically used hydroxyl radical trap, reduces the myonecrosis and the mortality caused by an experimental infection with C. perfringens in a model of gas gangrene. This knowledge provides new insights towards developing novel therapies aimed to reduce tissue damage during clostridial myonecrosis.