Time course of inflammatory cytokines in acute ischemic stroke patients and their relation to inter-alfa trypsin inhibitor heavy chain 4 and outcome Full Text
Annals of the Indian Academy of Neurology, 08/17/2012
Nayak AR et al. – Serial measurement of IL–10, IL–2 and TNF–a and ITIH4 may be useful for the follow–up of clinical outcome after acute ischemic stroke (AIS).Methods
- A panel of 12 inflammatory cytokines and ITIH4 were estimated in serial blood samples collected at admission, 24 h, 48 h, 72 h, 144 h and at discharge of AIS patients (n=5).
- Out of the 12 cytokines, only interleukin (IL)-2, tumor necrosis factor-alfa (TNF-a), IL-10, IL-6, IL-1B and IL-8 were in the measurable range of the kit (10 pg/mL).
- The authors found high IL-2 at admission, which decreased (P < 0.05) in the follow-up samples.
- TNF-a initially increases (P<0.05) at 24 h followed by gradual decrease (P<0.05) after 72 h.
- IL-10 decreases initially (P<0.05) till 72 h as compared with its level at admission and then increases (P < 0.05) after 144 h.
- Similarly, ITIH4 was down-regulated in the early 72 h followed by further increase with improvement of the patient.
- ITIH4 correlates with IL-10 and computed tomography scan infarct volume.
- Serum IL-6, IL-1B and IL-8 increased in the AIS patients, but did not show any pattern.