HTLV-1 Associated Infective Dermatitis: Updates on the Pathogenesis
Experimental Dermatology, 08/20/2012
McGill NK et al. – Genetic factors within ethnic groups determine host immune response and carrier state or disease manifestation of human T–cell lymphotropic virus (HTLV) type 1 infection. Increased IgE levels may contribute to the staphyloccocus aureus and beta haemolytic streptococci superinfection in HTLV–1 associated infective dermatitis (HAID). Additionally, the possible impact of filaggrin, skin proteinase dysregulation, Langerhans cell dysfunction and TH2 chemokines are highlighted. More than 45 years since the discovery of HAID the exact pathogenesis is still not fully understood.