Podosomes in migrating microglia: components and matrix degradation
Journal of Neuroinflammation, 08/10/2012
Vincent C et al. – The discovery of functional podosomes in microglia has broad implications, because migration of these innate immune cells is crucial in the developing brain, after damage, and in disease states involving inflammation and matrix remodeling. Based on the roles of invadosomes in peripheral tissues, the authors propose that microglia use these complex structures to adhere to and degrade the ECM for efficient migration.