Impact of genetic ancestry and socio-demographic status on the clinical expression of systemic lupus erythematosus in Amerindian-European populations
Arthritis & Rheumatism, 08/09/2012
Sanchez E et al. – In general, genetic Amerindian ancestry correlates with lower socio–demographic status and increases the risk for developing renal involvement and systemic lupus erythematosus at an earlier age of onset.Methods
- A total of 2116 SLE patients of Amerindian-European origin and 4001 SLE patients of European descent with clinical data were used in the study.
- Genotyping of 253 continental ancestry informative markers was performed on the Illumina platform.
- The STRUCTURE and ADMIXTURE software were used to determine genetic ancestry of each individual.
- Correlation between ancestry and socio-demographic and clinical data were analyzed using logistic regression.
- The average Amerindian genetic ancestry of 2116 SLE patients was 40.7%.
- There was an increased risk of having renal involvement (P<0.0001, OR= 3.50 95%CI 2.63-4.63) and an early age of onset with the presence of Amerindian genetic ancestry (P<0.0001).
- Amerindian ancestry protected against photosensitivity (P<0.0001, OR= 0.58 95%CI 0.44-0.76), oral ulcers (P<0.0001, OR= 0.55 95%CI 0.42-0.72), and serositis (P<0.0001, OR= 0.56 95%CI 0.41-0.75) after adjustment by age, gender and age of onset.
- However, gender and age of onset had stronger effects on malar rash, discoid rash, arthritis and neurological involvement than genetic ancestry.