The intensity of immune activation is linked to the level of CCR5 expression in human immunodeficiency virus type 1-infected persons
Portales P et al. – CCR5 density remained unchanged after highly active anti–retroviral therapy (HAART) introduction or cessation, whereas CD38 expression decreased and increased, respectively. Moreover, pre–therapeutic CCR5 density was highly predictive of residual CD38 over–expression after 9months of HAART. Hence, CCR5 might play an immunological role in HIV–1 infection as a driver of immune activation.