Laquinimod modulates B cells and their regulatory effects on T cells in Multiple Sclerosis
Journal of Neuroimmunology, 07/31/2012
Toubi E et al. – Laquinimod modulated B cell markers, mainly by increasing the regulatory ones CD25, IL10 and CD86, and decreased IL4, while increasing IL10 and TGFβ in both B and T cells, in a B cell–mediated manner. These findings shed additional light on the mechanisms underlying the effects of laquinimod in Multiple Sclerosis (MS)and potentially other immune–mediated diseases.