Frequency and distribution of asymptomatic brain lesions in patients with β-thalassemia intermedia
Annals of Hematology, 08/03/2012
Karimi M et al. – Although in univariate analysis either splenectomy or thrombocytosis showed significant correlation with the presence of single or multiple white matter lesions (WML, thrombocytosis by itself did not significantly contribute in developing asymptomatic brain lesions. The lack of significant correlation between lesions and regular blood transfusions could be related to the treatment with hydroxyurea (HU) in untransfused patients, which increased fetal hemoglobin levels and improved the morphology and the pathological indices of the red blood cells.