Risk Association Between the NF-κB1 -94ins/delATTG Promoter Polymorphism and Inflammatory Bowel Diseases: A Meta-Analysis
Digestive Diseases and Sciences, 08/03/2012
Liang M et al. – This meta–analysis indicated that the NF–κB1 –94ins/delATTG promoter polymorphism is a risk factor for ulcerative colitis (UC) but not Crohn’s disease (CD).Methods
- All eligible case–control studies of the association of NF-κB1 -94ins/delATTG promoter polymorphism with UC and CD were identified in the Pubmed and Embase databases.
- From these data, odds ratios (OR) with 95 % confidence intervals (CI) were calculated.
- Meta-analysis was performed for alleles (D vs. W) and genotypes (DD + WD vs. WW, DD vs. WW + WD, DD vs. WW, WD vs. WW) in a fixed/random effects model.
- Nine case–control studies that included 4,447 cases (2,631 UC and 1,816 CD) and 2,195 controls were identified.
- Results indicated increased risk association of D allele carriers with UC (D vs. W: OR=1.08, 95 % CI=1.01-1.17, P=0.03; DD vs. WW + WD: OR=1.16, 95 % CI=1.01-1.32, P=0.04 and DD vs. WW: OR=1.20, 95 % CI=1.03-1.39, P=0.02).
- No risk association was identified with CD.