Modulation of immune signalling by inhibitors of apoptosis
Trends in Immunology, 07/27/2012
Beug ST et al. – The regulation of immunity by the inhibitor of apoptosis (IAP) is primarily mediated through the ubiquitin ligase function of cellular IAP (cIAP)1, cIAP2, and X–linked IAP (XIAP), the targets of which impact nuclear factor (NF)–κB and mitogen–activated protein kinase (MAPK) signalling pathways. In addition, neuronal apoptosis inhibitory protein (NAIP), cIAP1, and cIAP2 modulate innate immune responses through control of the inflammasome complex.