Fish consumption, insulin sensitivity and beta-cell function in the insulin resistance atherosclerosis study (iras)
Nutrition, Metabolism & Cardiovascular Diseases, 07/27/2012
Lee C et al. – Fish consumption was not associated with measures of insulin sensitivity in the multi–ethnic Insulin Resistance Atherosclerosis Study (IRAS) cohort. However, higher fish consumption may be associated with pancreatic beta–cell dysfunction.Methods
- Authors examined the cross–sectional association between fish consumption and measures of insulin sensitivity and secretion in 951 non–diabetic participants in the Insulin Resistance Atherosclerosis Study (IRAS).
- Fish consumption, categorized as <2 vs. ≥2 portions/week, was measured using a validated food frequency questionnaire.
- Insulin sensitivity (SI) and acute insulin response (AIR) were determined from frequently sampled intravenous glucose tolerance tests.
- Higher fish consumption was independently associated with lower SI–adjusted AIR (β = –0.13 [–0.25, –0.016], p = 0.03, comparing ≥2 vs. <2 portions/week).
- Fish consumption was positively associated with intact and split proinsulin/C–peptide ratios, however, these associations were confounded by ethnicity (multivariable–adjusted β = 0.073 [–0.014, 0.16] for intact proinsulin/C–peptide ratio, β= 0.031 [–0.065, 0.13] for split proinsulin/C–peptide ratio).
- Authros also observed a significant positive association between fish consumption and fasting blood glucose (multivariable–adjusted β = 2.27 [0.68, 3.86], p = 0.005).
- They found no association between fish consumption and SI (multivariable–adjusted β = –0.015 [–0.083, 0.053]) or fasting insulin (multivariable–adjusted β = 0.016 [–0.066, 0.10]).