Isothermal microcalorimetry for antifungal susceptibility testing of Mucorales, Fusarium spp., and Scedosporium spp.
Diagnostic Microbiology and Infectious Disease, 07/16/2012
Tafin UF et al. – The percentage of agreement (within one 2–fold dilution) between the MHIC and MIC (or MEC) was 67%, 92%, 75%, and 83% for amphotericin B, voriconazole, posaconazole, and caspofungin, respectively. Microcalorimetry provides additional information on timing of antifungal activity, enabling further investigation of drug–mold and drug–drug interaction, and optimization of antifungal treatment.