Evaluation of Modification of Diet in Renal Disease study and Cockcroft-Gault equations for sitagliptin dosing
Journal of Nephrology, 07/17/2012
McFarland MS et al. – Overall there was agreement in sitagliptin dose using Modification of Diet in Renal Disease and Cockcroft–Gault equations. Discrepancies resulted in underestimation of sitagliptin dose at estimated creatinine clearance (eCLCr) above 50 ml/min and overestimation at lower eCLCr. Clinical implications are the potential for excessive dosing of sitagliptin and other agents with similar dose stratification by eCLCr in individuals with kidney dysfunction.