Reconciling views on T cell receptor germline bias for MHC
Trends in Immunology, 07/16/2012
Garcia KC et al. – Whether MHC restriction by the T cell receptor (TCR) is a product of evolutionary pressures leading to germline–encoded ‘rules of engagement’ remains avidly debated. Structural results derived from analysis of TCR-peptide–MHC complexes appear to support a model of physical specificity between TCR germline V regions and MHC.