Leptin and dementia over 32 years--The Prospective Population Study of Women
Alzheimer's & Dementia, 07/05/2012
Gustafson DR et al. – Leptin is not a mid–life marker of late–life dementia risk in this population sample of Swedish women born between 1908 and 1930.Methods
- A longitudinal cohort study, the Prospective Population Study of Women, in Gothenburg, Sweden, includes a representative sample of 1462 women followed from mid-life ages of 38 to 60 years to late-life ages of 70 to 92 years.
- Women were examined in 1968, 1974, 1980, 1992, and 2000 using neuropsychiatric, anthropometric, clinical, and other measurements.
- Serum leptin was measured on samples collected at the 1968 baseline examination, after storage at -20°C for 29 years.
- Cox proportional hazards regression models estimated incident dementia risk by baseline leptin.
- Logistic regression models related leptin levels to dementia among surviving participants 32 years later.
- All models were adjusted for multiple potential confounders.
- Mid-life leptin was not related to dementia risk using Cox or logistic regression models.
- This was observed despite positive baseline correlations between leptin and adiposity measures, and given the previous report of high mid-life waist-to-hip ratio being related to a twofold higher dementia risk.