Postnatal development of transmural gradients in expression of ion channels and Ca2+-handling proteins in the ventricle
Journal of Molecular and Cellular Cardiology, 07/17/2012
Allah ESHA et al. – If the postnatal changes in ion channel mRNAs are used to predict changes in ionic conductances, mathematical modelling predicts the changes in action potential duration (APD) observed experimentally. It is concluded that many of the well known transmural gradients in the ventricle develop postnatally.