Sensitivity of minimal residual disease in acute myeloid leukaemia in first remission - methodologies in relation to their clinical situation
British Journal of Haematology, 06/29/2012
Hokland P et al. – For multicolour flow cytometry (MFC), sensitivity is likewise largely a function on whether the same phenotype is seen in normal immature cells and, in addition, antigen drift/shift with leukaemia–associated immunophenotypes (LAIPs) changing at relapse is a well–known problem. In considering which sensitivity to opt for, a further variable is the situation of patient, most importantly the level of cytoreduction intended.