The cardiovascular effects of midazolam co-induction to propofol for induction in aged patients Full Text
Korean Journal of Anesthesiology, 06/26/2012
Clinical Article
Lim YS et al. – Co–induction with midazolam and propofol could prevent a marked blood pressure (BP) decrease at tracheal intubation for induction in aged patients.
Methods- Eighty patients over 65years (ASA physical status 1, 2) scheduled for elective surgery received general anesthesia with remifentanil and propofol or midazolam.
- Patients in group P (n=40) were induced with 0.9% NaCl 0.03ml/kg, propofol 1. 2mg/kg and remifentanil.
- Patients in group MP (n=40) were induced with midazolam 0.03mg/kg, propofol 0.8mg/kg and remifentanil.
- The time taken to reach loss of consciousness (LOC) and the value of bispectral index score (BIS) at LOC were recorded.
- After LOC, 0.8mg/kg of rocuronium was given and tracheal intubation was performed.
- The mean blood pressure (MBP) and heart rate (HR) were recorded before induction as the base value, before intubation, immediately post–intubation and 3minutes after intubation.
- Compared with the base values, MBP at before intubation and 3minutes after intubation was significantly decreased in group P and group MP (P<0.05).
- Compared with group P, the decrease of MBP was significantly less at before intubation, immediately after intubation and 3minutes after intubation in group MP (P<0.05).
- The time taken to reach LOC was significantly decreased in group MP compared with that in group P (P<0.05).
- There were no significant differences of HR at any time between the two groups.
