Novel patch for transdermal administration of morphine
Journal of Pain and Symptom Management, 07/16/2012
Inui N et al. – These data provide useful information for developing a transdermal morphine system.Methods
- In this study, the transdermal morphine hydrochloride patch was administered to intact skin in five subjects and the plasma concentrations of morphine and its metabolites were examined.
- Morphine was absorbed systemically, producing plasma morphine concentrations above the assay detection limit by at least 24 hours after attachment of patches containing a total dose of 180mg of morphine.
- The levels gradually increased in a time–dependent manner without serious events.
- The area under the concentration–time curve from 0 to 72 hours (AUC0–72) values for morphine, morphine–6–glucuronide, and morphine–3–glucuronide were 60.4±13.4, 133.7±17.4, and 861.5±126.7ng•h/mL, respectively.
- The mean plasma area under the concentration–time curve from 0 to 72 hours ratio for morphine–6–glucuronide relative to morphine was 2.64.