Leptin signaling in adipose tissue: role in lipid accumulation and weight gain
Circulation Research, 07/11/2012
Singh P et al. – In healthy humans, increases in leptin, as seen with modest weight gain, may increase caveolin–1 expression in adipose tissue. Increased caveolin–1 expression in turn impairs leptin signaling and attenuates leptin–dependent lowering of intra–cellular lipid accumulation. These study suggests a leptin–dependent feedback mechanism which may be essential to facilitate adipocyte lipid storage during weight gain.