The efficacy of TACE combined sorafenib in advanced stages hepatocellullar carcinoma Full Text
BMC Cancer, 06/22/2012
Qu X et al. – Transarterial chemoembolization (TACE) combined sorafenib significantly prolonged median overall survival time of patients with advanced hepatocellullar carcinoma (HCC).Methods
- Between June 2008 and Feb 2011, 45 patients with advanced HCC were enrolled and treated with sorafenib in combination with TACE according to an institutional protocol of the Zhongshan hospital, Fudan University.
- The control group of 45 other HCC patients with similar characteristics treated with TACE alone in the same period of time in the institute were selected for retrospective comparison of the treatment outcomes especially overall survival time.
- Adverse reactions induced by sorafenib were observed and recorded.
- The median overall survival time of the combined treatment group was 27 (95% Confidence Interval: 21.9–32.1) months, and that of TACE alone group was 17 months (95% Confidence Interval: 8.9–25.0) months (P = 0.001).
- Patients required significantly less frequent TACE for their symptomatic treatment after the initiation of sorafenib therapy.
- The most common adverse events associated with sorafenib were hand–foot skin reaction, rash and diarrhea.
- Of CTCAE grade IV or V toxicity was observed.