NFATc2 Is a Potential Therapeutic Target in Human Melanoma
Journal of Investigative Dermatology, 06/22/2012
Perotti V et al. – Calcineurin/NFATc2 targeting significantly enhanced melanoma cell death induced by antitumor agents, such as MEK– or BRAFV600E–specific inhibitors, and tumor necrosis factor–related apoptosis–inducing ligand, which trigger the intrinsic or extrinsic pathway of apoptosis, respectively. These findings identify NFATc2 as a potential therapeutic target in melanoma.