B-cell-activating factor enhances interleukin-6 and interleukin-10 production by ODN-activated human B cells
Scandinavian Journal of Immunology, 06/22/2012
Yehudai D et al. – The authors found that addition of BAFF did not enhance the expression of TLR–9, CD69, and MHC–II in ODN–activated B cells. Incubation of B cells with BAFF and ODN together, lead to a marked elevation of IL–6 and IL–10 levels compared to ODN alone. Synthesis and mitosis were higher in B cells stimulated by BAFF than in B cells stimulated by ODN. These findings suggest that both BAFF and TLR9 contribute independently to B cell function.