Exploring the value of apoB48 as a marker for atherosclerosis in clinical practice
European Journal of Clinical Investigation, 06/26/2012
Alipour A et al. – ApoB48 concentrations are highest in patients with familial combined hyperlipidaemia (FCH) and in atherosclerotic subjects with type 2 diabetes mellitus (T2DM). In patients not using statins, the surrogate atherosclerosis marker Intima–media thickness (IMT) correlates best with apoB48, suggesting that fasting apoB48 may help to detect subjects at risk.Methods
- Treated patients with FCH (18), FH (20), T2DM (26), CAD (65), T2DM with CAD (T2DM/CAD) (28) and 33 healthy controls were included.
- Intima–media thickness (IMT) measurements were carried out to investigate subclinical atherosclerosis.
- LDL–C and total apoB were lowest in patients with T2DM/CAD owing to the more frequent use of lipid–lowering medication.
- Fasting plasma apoB48 was elevated in patients with FCH (11.38 ± 1.50 mg/L) and T2DM/CAD (9.65 ± 1.14 mg/L) compared with the other groups (
anova, P < 0.01).
- CAD patients (8.09 ± 0.57 mg/L) had higher apoB48 levels than controls (5.74 ± 0.55 mg/L) and FH patients (5.40 ± 0.51 mg/L) (P = 0.02).
- The lowest IMT was measured in controls (0.56 ± 0.02 mm) and FCH patients (0.60 ± 0.03 mm).
- In the total group, the best association for apoB48 was found with fasting triglyceride (Pearson's r = 0.72, P < 0.001).
- In the subjects not using statins (n = 74), the best correlation was found with IMT (r = 0.52; P < 0.001), whereas total apoB was not associated with IMT (r = 0.20, P = 0.12).