Comparison of the effects of different statins and doses on lipid levels in patients with diabetes: Results from VOYAGER
Nutrition, Metabolism & Cardiovascular Diseases, 06/19/2012
Karlson BW et al. – This meta–analysis of 8859 patients with diabetes mellitus shows favourable effects on lipids with the three statins studied, in line with results for the overall VOYAGER population. The importance of using an effective statin at an effective dose to reach treatment goals for such high–risk patients is evident.Methods
- The VOYAGER database included individual patient data from 37 studies involving comparisons of rosuvastatin with either atorvastatin or simvastatin.
- Of the 32 258 patients included, 8859 (27.5%) had diabetes.
- Rosuvastatin appeared to be the most efficacious of the three statins, both for lowering LDL–C and for reaching a target level of <70 mg dl–1 for LDL–C.
- It was also more effective than atorvastatin at raising high–density lipoprotein cholesterol in the diabetes population.
- These results are consistent with the overall VOYAGER results.