Activation of HIF-1 by metallothionein contributes to cardiac protection in the diabetic heart
American Journal of Physiology - Heart and Circulatory Physiology, 06/26/2012
Xue W et al. – Authors demonstrated that MT–enhanced HIF–1α activity is likely through a mechanism of protein nuclear translocation. These results suggest that MT induces HIF–1α expression, leading to increased HK–II in the diabetic heart.