Downregulation of TLR7/9 leads to deficient production of IFN-α from plasmacytoid dendritic cells in chronic hepatitis B
Inflammation Research, 06/14/2012
Xu N et al. – Impaired IFN–α production from plasmacytoid dendritic cells (pDCs) may contribute to the immunopathogenesis of chronic hepatitis B virus (HBV) infection, which may be the result of a reduced amount of pDCs as well as decreased expression of Toll–like receptor (TLR)7 and TLR9 on pDCs.



